| Mannitol dose-dependently attenuates lung reperfusion injury following liver ischemia reperfusion: a dose-response study in an isolated perfused double-organ model. | |
| | |
MedLine Citation:
|
PMID: 12647234 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We had previously studied different modes of prevention of liver ischemia-reperfusion (IR)-induced remote organ reperfusion injury, a challenge that remains partly unmet. We have now studied the capability of mannitol at different doses in abrogating liver IR-induced lung reperfusion injury in an isolated double-organ model. Rat livers ( n = 8/group) were perfused with Krebs-Henseleit solution (control) or made globally ischemic (IR) for 2 h, after which they were paired with normal lungs and "reperfused" together for 15 min. The lungs were then perfused alone with the accumulated Krebs for an additional 45 min. Another 4 control and 4 IR pairs were reperfused with Krebs containing mannitol at.22 mmol,.55 mmol,.77 mmol, or 1.1 mmol. Mannitol.22 mmol and 1.1 mmol failed to attenuate IR-lung injury as indicated by 50-95% increases in inspiratory and perfusion pressures and compliance reduction, a 70% increase in weight gain, and a 2-50-fold increase in bronchoalveolar lavage volume and content. Mannitol.55 mmol prevented all these abnormalities, and.77 mmol attenuated only changes in ventilatory parameters. The latter two treatments were also associated with a 50% reduction in xanthine oxidase activity and a 35-45% increase in the reduced glutathione tissue content compared with the nontreated IR-paired lungs. It is concluded that mannitol in a narrow therapeutic dose range can reduce oxidalive stress-induced lung damage that is related to liver IR. |
| | |
Authors:
|
A A Weinbroum; I Shapira; R Ben-Abraham; A Szold; R B Abraham |
Related Documents
:
|
12812414 - Impedance spectroscopy for monitoring ischemic injury in the intestinal mucosa. 3076884 - Reperfusion injury. 10728354 - Preconditioning the human myocardium by simulated ischemia: studies on the early and de... 7944694 - Pentostatin-augmented interstitial adenosine prevents postcardioplegia injury in damage... 7628134 - Myocardial dysfunction and abnormal left ventricular exercise response in autonomic dia... 20192244 - Differential metabolomics for quantitative assessment of oxidative stress with strenuou... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Lung Volume: 180 ISSN: 0341-2040 ISO Abbreviation: Lung Publication Date: 2002 |
Date Detail:
|
Created Date: 2003-03-20 Completed Date: 2003-06-20 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7701875 Medline TA: Lung Country: United States |
Other Details:
|
Languages: eng Pagination: 327-38 Citation Subset: IM |
Affiliation:
|
The Post-Anesthesia Care Unit and Animal Research Laboratory, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. draviw@tasmc.health.gov.il |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Diuretics, Osmotic / administration & dosage*, therapeutic use Dose-Response Relationship, Drug Liver / blood supply* Lung / blood supply* Male Mannitol / administration & dosage*, therapeutic use Perfusion Rats Rats, Wistar Reperfusion Injury / prevention & control* |
| Chemical | |
Reg. No./Substance:
|
0/Diuretics, Osmotic; 69-65-8/Mannitol |
| Comments/Corrections | |
Erratum In:
|
Lung. 2003;181(2):113 Note: Abraham R B [corrected to Ben-Abraham R] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Inhaled ultrasonically nebulized distilled water decreases exhaled nitric oxide in asthma.
Next Document: Antileukinate, a hexapeptide inhibitor of CXC-chemokine receptor, suppresses bleomycin-induced acute...