Document Detail

Mannitol dose-dependently attenuates lung reperfusion injury following liver ischemia reperfusion: a dose-response study in an isolated perfused double-organ model.
MedLine Citation:
PMID:  12647234     Owner:  NLM     Status:  MEDLINE    
We had previously studied different modes of prevention of liver ischemia-reperfusion (IR)-induced remote organ reperfusion injury, a challenge that remains partly unmet. We have now studied the capability of mannitol at different doses in abrogating liver IR-induced lung reperfusion injury in an isolated double-organ model. Rat livers ( n = 8/group) were perfused with Krebs-Henseleit solution (control) or made globally ischemic (IR) for 2 h, after which they were paired with normal lungs and "reperfused" together for 15 min. The lungs were then perfused alone with the accumulated Krebs for an additional 45 min. Another 4 control and 4 IR pairs were reperfused with Krebs containing mannitol at.22 mmol,.55 mmol,.77 mmol, or 1.1 mmol. Mannitol.22 mmol and 1.1 mmol failed to attenuate IR-lung injury as indicated by 50-95% increases in inspiratory and perfusion pressures and compliance reduction, a 70% increase in weight gain, and a 2-50-fold increase in bronchoalveolar lavage volume and content. Mannitol.55 mmol prevented all these abnormalities, and.77 mmol attenuated only changes in ventilatory parameters. The latter two treatments were also associated with a 50% reduction in xanthine oxidase activity and a 35-45% increase in the reduced glutathione tissue content compared with the nontreated IR-paired lungs. It is concluded that mannitol in a narrow therapeutic dose range can reduce oxidalive stress-induced lung damage that is related to liver IR.
A A Weinbroum; I Shapira; R Ben-Abraham; A Szold; R B Abraham
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lung     Volume:  180     ISSN:  0341-2040     ISO Abbreviation:  Lung     Publication Date:  2002  
Date Detail:
Created Date:  2003-03-20     Completed Date:  2003-06-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7701875     Medline TA:  Lung     Country:  United States    
Other Details:
Languages:  eng     Pagination:  327-38     Citation Subset:  IM    
The Post-Anesthesia Care Unit and Animal Research Laboratory, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
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MeSH Terms
Diuretics, Osmotic / administration & dosage*,  therapeutic use
Dose-Response Relationship, Drug
Liver / blood supply*
Lung / blood supply*
Mannitol / administration & dosage*,  therapeutic use
Rats, Wistar
Reperfusion Injury / prevention & control*
Reg. No./Substance:
0/Diuretics, Osmotic; 69-65-8/Mannitol
Erratum In:
Lung. 2003;181(2):113
Note: Abraham R B [corrected to Ben-Abraham R]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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