| Mannitol bolus preferentially shrinks non-infarcted brain in patients with ischemic stroke. | |
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MedLine Citation:
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PMID: 11739839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Changes in brain tissue volume in six patients who had acute complete middle cerebral artery (MCA) infarctions and CT evidence of midline shift were measured using the brain boundary shift integral (BBSI) on sequential T1-weighted MR images acquired before and after a 1.5-g/kg bolus infusion of mannitol. At 50 to 55 minutes after the baseline scan, total brain volume decreased by 8.1 +/- 2.8 mL (0.6%, p < 0.005). Brain in the noninfarcted hemisphere shrank more (0.8 +/- 0.4%) than in the infarcted hemisphere (0.0 +/- 0.5%, p < 0.05). |
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Authors:
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T O Videen; A R Zazulia; E M Manno; C P Derdeyn; R E Adams; M N Diringer; W J Powers |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neurology Volume: 57 ISSN: 0028-3878 ISO Abbreviation: Neurology Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2001-12-12 Completed Date: 2002-01-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: 2120-2 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology and Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA. tom@npg.wustl.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Atrophy Brain / drug effects, pathology Brain Edema / diagnosis, drug therapy* Brain Mapping Disease Progression Dominance, Cerebral / drug effects, physiology Female Humans Infarction, Middle Cerebral Artery / diagnosis, drug therapy* Infusions, Intravenous Magnetic Resonance Imaging* Male Mannitol / administration & dosage, adverse effects* Middle Aged Tomography, X-Ray Computed* |
| Grant Support | |
ID/Acronym/Agency:
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NS35966/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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69-65-8/Mannitol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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