Document Detail

Mankind's first natural stem cell transplant.
MedLine Citation:
PMID:  20141549     Owner:  NLM     Status:  MEDLINE    
The timing of the umbilical cord clamping at birth is still controversial. In the modern era of medicine, the cord has been clamped early to facilitate resuscitation and stabilization of infants. However, recently delayed cord clamping has been supported by physicians because it allows for the physiological transfer of blood from the placenta to the infant. Many clinical studies have revealed that the delayed cord clamping elevates blood volume and haemoglobin and prevents anaemia in infants. Moreover, since it was known that umbilical cord blood contains various valuable stem cells such as haematopoietic stem cells, endothelial cell precursors, mesenchymal progenitors and multipotent/pluripotent lineage stem cells, the merit of delayed cord clamping has been magnified. In this review, we discuss the advantages and disadvantages of delayed cord clamping at birth. We highlight the importance of delayed cord clamping in realizing mankind's first stem cell transfer and propose that it should be encouraged in normal births.
Jose N Tolosa; Dong-Hyuk Park; David J Eve; Stephen K Klasko; Cesario V Borlongan; Paul R Sanberg
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-02-05
Journal Detail:
Title:  Journal of cellular and molecular medicine     Volume:  14     ISSN:  1582-4934     ISO Abbreviation:  J. Cell. Mol. Med.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-04-26     Completed Date:  2010-08-10     Revised Date:  2010-12-21    
Medline Journal Info:
Nlm Unique ID:  101083777     Medline TA:  J Cell Mol Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  488-95     Citation Subset:  IM    
Department of Pediatrics, Division Neonatology, University of South Florida, College of Medicine, Tampa, FL 33612, USA.
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MeSH Terms
Cord Blood Stem Cell Transplantation*
Infant, Newborn
Perinatal Care / methods*
Time Factors
Umbilical Cord / blood supply*
Comment In:
J Cell Mol Med. 2010 Dec;14(12):2840-1   [PMID:  21040456 ]

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