Document Detail

Manipulation of the tumour-associated vasculature to improve tumour therapy.
MedLine Citation:
PMID:  12604049     Owner:  NLM     Status:  MEDLINE    
Inhibition of tumour vascular growth, destruction of the tumour associated vasculature (TAV), and manipulation of the endothelial lining of the TAV provide powerful tools for anti-tumour therapy. We previously demonstrated that addition of TNF to chemotherapy improved tumour response. The major effect of TNF is an increased permeability of the tumour vascular bed resulting in augmented accumulation of co-administered drug in the tumour. As the TAV is recognised as a major candidate in tumour therapy it is becoming important to understand anti-vascular effects better. In our laboratory we examine the effect of immunotherapy on the TAV, and the effect of anti tumour-vascular therapy on tumours. This is studied in animal models, which exhibit similarities with the clinical setting, such as tumour perfusion treatment.
Timo L M ten Hagen; Alexander M M Eggermont
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of liposome research     Volume:  12     ISSN:  0898-2104     ISO Abbreviation:  J Liposome Res     Publication Date:    2002 Feb-May
Date Detail:
Created Date:  2003-02-26     Completed Date:  2003-04-22     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9001952     Medline TA:  J Liposome Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  149-54     Citation Subset:  IM    
Dept of Surgical Oncology, Laboratory for Experimental Surgical Oncology, Erasmus University Rotterdam, The Netherlands.
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MeSH Terms
Neoplasms / therapy*
Neoplasms, Experimental / therapy
Neovascularization, Pathologic
Time Factors
Tumor Necrosis Factor-alpha / metabolism
Reg. No./Substance:
0/Tumor Necrosis Factor-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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