| Manipulation of outer root sheath cell survival perturbs the hair-growth cycle. | |
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MedLine Citation:
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PMID: 10393176 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transgenic mice that overexpress the anti-apoptotic gene bcl-xL under the control of the keratin 14 promoter have significantly shorter hair than non-transgenic littermates. The deficit in hair length correlated with a decrease in the duration of anagen, the growth phase of the hair cycle. A prolongation in telogen, the resting phase of the hair cycle, was also observed in adult animals. In the developing hair bulb, bcl-xL transgene expression was observed exclusively in the outer root sheath (ORS) cells. Bcl-xL expression enhanced the survival of ORS cells treated with apoptotic stimuli. The results suggest that preventing the apoptotic death of ORS cells during anagen leads to a more rapid termination of progenitor cell commitment/proliferation, while the increased survival of ORS cells during telogen delays the initiation of a new hair cycle. ORS cells produce fibroblast growth factor-5 (FGF-5), which acts in a paracrine fashion to terminate precursor cell division during anagen. The short hair phenotype of bcl-xL transgenic mice was substantially reversed in FGF-5-deficient mice. Thus, the production of growth inhibitory factors by ORS cells may provide a mechanism through which the hair-growth cycle is regulated by cell survival. |
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Authors:
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J C Pena; A Kelekar; E V Fuchs; C B Thompson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The EMBO journal Volume: 18 ISSN: 0261-4189 ISO Abbreviation: EMBO J. Publication Date: 1999 Jul |
Date Detail:
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Created Date: 1999-08-31 Completed Date: 1999-08-31 Revised Date: 2008-11-20 |
Medline Journal Info:
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Nlm Unique ID: 8208664 Medline TA: EMBO J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 3596-603 Citation Subset: IM |
Affiliation:
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The Gwen Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, IL 60637, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / radiation effects Cell Differentiation Cell Division / radiation effects Cell Survival / radiation effects Epidermis / metabolism Female Fibroblast Growth Factor 5 Fibroblast Growth Factors / deficiency, genetics, physiology Gene Deletion Gene Expression Hair / cytology, growth & development*, metabolism, radiation effects Hair Follicle / cytology*, growth & development, metabolism, radiation effects Male Mice Mice, Knockout Mice, Transgenic Phenotype Proto-Oncogene Proteins c-bcl-2 / genetics, metabolism* Stem Cells / cytology*, metabolism, radiation effects Ultraviolet Rays bcl-X Protein |
| Chemical | |
Reg. No./Substance:
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0/Bcl2l1 protein, mouse; 0/Fgf5 protein, mouse; 0/Proto-Oncogene Proteins c-bcl-2; 0/bcl-X Protein; 129653-64-1/Fibroblast Growth Factor 5; 62031-54-3/Fibroblast Growth Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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