Document Detail

Manidipine improves spermatogenesis in the stroke-prone spontaneously hypertensive rat.
MedLine Citation:
PMID:  9154516     Owner:  NLM     Status:  MEDLINE    
We evaluated the protective effects of manidipine, which is a long-lasting calcium-channel blocker, against damage to spermatogenesis arising from hypertensive vascular changes in stroke-prone spontaneously hypertensive rats (SHRSP). SHRSP showed severe hypertension at 11 weeks of age, followed by hypertensive changes in intratesticular arterioles from 15 weeks of age. Manidipine lowered the blood pressure and the hypertensive vascular changes of intratesticular arterioles in SHRSP. The percentages of atrophic seminiferous tubules and tubules with less-differentiated germ cells were increased in SHRSP at 23 weeks of age, although the administration of manidipine preserved spermatogenesis at a normal level. The transferrin concentration in testicular cytosol was comparable, whereas insulin-like growth factor-I (IGF-I) was reduced from 19 weeks of age in SHRSP. Manidipine preserved the normal IGF-I concentration. Therefore, manidipine prevented the development of hypertensive vascular changes in the testis and maintained normal Sertoli cell function. As a result, manidipine protected spermatogenesis in SHRSP. These findings also suggested that hypertensive vascular changes in the testes play the most important role in spermatogenic damage in SHRSP.
K Akagashi; Y Kumamoto; N Itoh; T Tsukamoto; T Suzuki; Y Ohta
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of andrology     Volume:  18     ISSN:  0196-3635     ISO Abbreviation:  J. Androl.     Publication Date:    1997 Mar-Apr
Date Detail:
Created Date:  1997-07-22     Completed Date:  1997-07-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8106453     Medline TA:  J Androl     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  210-6     Citation Subset:  IM    
Department of Urology, Sapporo Medical University School of Medicine, Hokkaido, Japan.
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MeSH Terms
Antihypertensive Agents / pharmacology*
Arterioles / drug effects,  pathology,  physiopathology
Blood Pressure / drug effects
Dihydropyridines / pharmacology*
Hypertension / drug therapy,  pathology,  physiopathology*
Muscle, Smooth, Vascular / drug effects,  pathology,  physiopathology
Rats, Inbred SHR
Rats, Inbred WKY
Seminiferous Tubules / pathology
Spermatogenesis / drug effects*,  physiology
Testis / blood supply,  pathology*,  physiopathology
Reg. No./Substance:
0/Antihypertensive Agents; 0/Dihydropyridines; 89226-50-6/manidipine

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