| Manidipine improves spermatogenesis in the stroke-prone spontaneously hypertensive rat. | |
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MedLine Citation:
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PMID: 9154516 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated the protective effects of manidipine, which is a long-lasting calcium-channel blocker, against damage to spermatogenesis arising from hypertensive vascular changes in stroke-prone spontaneously hypertensive rats (SHRSP). SHRSP showed severe hypertension at 11 weeks of age, followed by hypertensive changes in intratesticular arterioles from 15 weeks of age. Manidipine lowered the blood pressure and the hypertensive vascular changes of intratesticular arterioles in SHRSP. The percentages of atrophic seminiferous tubules and tubules with less-differentiated germ cells were increased in SHRSP at 23 weeks of age, although the administration of manidipine preserved spermatogenesis at a normal level. The transferrin concentration in testicular cytosol was comparable, whereas insulin-like growth factor-I (IGF-I) was reduced from 19 weeks of age in SHRSP. Manidipine preserved the normal IGF-I concentration. Therefore, manidipine prevented the development of hypertensive vascular changes in the testis and maintained normal Sertoli cell function. As a result, manidipine protected spermatogenesis in SHRSP. These findings also suggested that hypertensive vascular changes in the testes play the most important role in spermatogenic damage in SHRSP. |
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Authors:
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K Akagashi; Y Kumamoto; N Itoh; T Tsukamoto; T Suzuki; Y Ohta |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of andrology Volume: 18 ISSN: 0196-3635 ISO Abbreviation: J. Androl. Publication Date: 1997 Mar-Apr |
Date Detail:
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Created Date: 1997-07-22 Completed Date: 1997-07-22 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8106453 Medline TA: J Androl Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 210-6 Citation Subset: IM |
Affiliation:
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Department of Urology, Sapporo Medical University School of Medicine, Hokkaido, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antihypertensive Agents / pharmacology* Arterioles / drug effects, pathology, physiopathology Atrophy Blood Pressure / drug effects Dihydropyridines / pharmacology* Hypertension / drug therapy, pathology, physiopathology* Male Muscle, Smooth, Vascular / drug effects, pathology, physiopathology Rats Rats, Inbred SHR Rats, Inbred WKY Seminiferous Tubules / pathology Spermatogenesis / drug effects*, physiology Testis / blood supply, pathology*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Dihydropyridines; 89226-50-6/manidipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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