| Manic symptoms in patients with depressive and/or anxiety disorders. | |
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MedLine Citation:
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PMID: 20338641 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Previous studies found that patients with depressive disorders frequently have lifetime manic symptoms or even an unrecognized bipolar disorder and that these patients have more severe illness. In this study we investigated whether the presence of significant manic symptoms among patients presenting with depressive and/or anxiety disorders is associated with more severe illness, more comorbidity, more suicidality and more atypical symptoms. METHODS: In a large cohort (n=2012) of persons with lifetime depressive and/or anxiety disorders (as confirmed with the Composite International Diagnostic interview (CIDI)) we used the 15-item Mood Disorder Questionnaire (MDQ) to assess the presence of lifetime manic symptoms. Patients with clinically recognized bipolar disorders were excluded from the study. RESULTS: Lifetime manic symptoms were present among 6.3% of the persons with depressive or anxiety disorders. Persons with lifetime manic symptoms more frequently had comorbid social phobia, generalized anxiety disorder and alcohol dependence, more frequently reported previous serious suicide attempts and their current depressive symptoms were more severe. Atypical depression symptoms were not more prevalent in persons with lifetime manic symptoms. LIMITATIONS: The presence of a lifetime manic or hypomanic episode was not assessed with the CIDI. CONCLUSIONS: Identifying lifetime manic symptoms with the MDQ in persons presenting with (unipolar) depressive or anxiety disorders, can not only help the recognition of actual bipolar disorder (as described in previous studies), but also the identification of a subgroup of patients with more severe symptomatology, more comorbid anxiety and alcohol dependence disorders, and more suicidality. |
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Authors:
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Belinda van den Berg; Brenda W J H Penninx; Frans G Zitman; Willem A Nolen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-24 |
Journal Detail:
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Title: Journal of affective disorders Volume: 126 ISSN: 1573-2517 ISO Abbreviation: J Affect Disord Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2010-12-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906073 Medline TA: J Affect Disord Country: Netherlands |
Other Details:
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Languages: eng Pagination: 252-6 Citation Subset: IM |
Copyright Information:
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Crown Copyright 2010. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Psychiatry/ EMGO Institute, VU University Medical Centre, Amsterdam, The Netherlands. belinda@animocentre.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Anxiety Disorders / psychology* Bipolar Disorder / diagnosis, psychology* Chi-Square Distribution Depressive Disorder / psychology* Female Humans Logistic Models Male Psychiatric Status Rating Scales Socioeconomic Factors Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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