| Mania: sympathoadrenal function and clinical state. | |
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MedLine Citation:
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PMID: 1876629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated sympathoadrenal and sympathetic nervous system activity, catecholamine disposition, and clinical state in 19 hospitalized manic patients. Severity of the core manic syndrome, anxiety, and hostility correlated with 24-hour urinary excretion of epinephrine relative to its metabolites, but only weakly with norepinephrine. Agitation, however, correlated most strongly and significantly with norepinephrine. Eight of the patients had mixed states: concurrent manic and depressive syndromes. There were no differences between mixed and pure manic patients with respect to catecholamine or metabolite excretion or precursor/product ratios, but mixed manic patients tended to have higher excretion of norepinephrine and had increased variance with respect to catecholamine measures. These data suggest that the function of the adrenal medulla, whether directly or indirectly, is important in the symptoms of both mixed and pure mania. |
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Authors:
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A C Swann; S K Secunda; S H Koslow; M M Katz; C L Bowden; J W Maas; J M Davis; E Robins |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Psychiatry research Volume: 37 ISSN: 0165-1781 ISO Abbreviation: Psychiatry Res Publication Date: 1991 May |
Date Detail:
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Created Date: 1991-09-20 Completed Date: 1991-09-20 Revised Date: 2008-04-17 |
Medline Journal Info:
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Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: IRELAND |
Other Details:
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Languages: eng Pagination: 195-205 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University of Texas Medical School, Houston 77225. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Medulla
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metabolism* Adult Anxiety / physiopathology Behavior / physiology Bipolar Disorder / metabolism*, physiopathology, psychology Catecholamines / metabolism* Epinephrine / urine Female Hostility Humans Male Methoxyhydroxyphenylglycol / urine Middle Aged Norepinephrine / urine Psychiatric Status Rating Scales Sympathetic Nervous System / metabolism* Vanilmandelic Acid / urine |
| Grant Support | |
ID/Acronym/Agency:
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MH-26975/MH/NIMH NIH HHS; MH-26977/MH/NIMH NIH HHS; MH-38084/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 534-82-7/Methoxyhydroxyphenylglycol; 55-10-7/Vanilmandelic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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