| Mania With and Without Depression in a Community Sample of US Adolescents. | |
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MedLine Citation:
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PMID: 22566563 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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CONTEXT: There are limited data on the manifestations of mania in general community samples of adolescents. OBJECTIVE: To present the prevalence and clinical correlates of mania with and without depressive episodes in a representative sample of US adolescents. DESIGN: Cross-sectional survey of adolescents using a modified version of the Composite International Diagnostic Interview. PARTICIPANTS: Ten thousand one hundred twenty-three adolescents aged 13 to 18 years identified in household and school settings. MAIN OUTCOME MEASURES: Mania/hypomania with or without depression among those who met DSM-IV criteria for bipolar I or II disorder or major depressive disorder. RESULTS: Two and a half percent of youth met criteria for lifetime bipolar I or II disorder and 1.7%, for mania only. Twelve-month rates of mania with and without depression were 2.2% and 1.3%, respectively. There was a nearly 2-fold increase in rates of mania from ages 13-14 to 17-18 years. Mania with depression was associated with a greater number of all indictors of clinical severity including symptom number and severity, role disability, severe impairment, comorbidity, and treatment compared with depression alone, whereas correlates of mania were similar among those with mania with or without depression. CONCLUSIONS: The increasing prevalence of bipolar disorder with increasing age and the comparable rate of bipolar disorder with those of adult samples highlight adolescence as the peak period of onset of mania. The clinical significance of mania plus depression as demonstrated by a 1 in 5 suicide attempt rate and nearly 2 months per year of role impairment in adolescence has important implications for early intervention. The evidence for independence of mania from depression warrants additional scrutiny in the diagnostic nomenclature and etiologic dissection of bipolar disorder. |
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Authors:
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Kathleen Ries Merikangas; Lihong Cui; G Kattan; Gabrielle A Carlson; Eric A Youngstrom; Jules Angst |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-7 |
Journal Detail:
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Title: Archives of general psychiatry Volume: - ISSN: 1538-3636 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372435 Medline TA: Arch Gen Psychiatry Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Intramural Research Program, National Institute of Mental Health, Bethesda, Maryland (Dr Merikangas and Mss Cui and Kattan); Stony Brook University School of Medicine, Stony Brook, New York (Dr Carlson); University of North Carolina at Chapel Hill (Dr Youngstrom); and Zurich University Hospital, Zurich, Switzerland (Dr Angst). |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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