Document Detail


Mango fruit peel and flesh extracts affect adipogenesis in 3T3-L1 cells.
MedLine Citation:
PMID:  22699857     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Obesity is associated with many chronic disease states, such as diabetes mellitus, coronary disease and certain cancers, including those of the breast and colon. There is a growing body of evidence that links phytochemicals with the inhibition of adipogenesis and protection against obesity. Mangoes (Mangifera indica L.) are tropical fruits that are rich in a diverse array of bioactive phytochemicals. In this study, methanol extracts of peel and flesh from three archetypal mango cultivars; Irwin, Nam Doc Mai and Kensington Pride, were assessed for their effects on a 3T3-L1 pre-adipocyte cell line model of adipogenesis. High content imaging was used to assess: lipid droplets per cell, lipid droplet area per cell, lipid droplet integrated intensity, nuclei count and nuclear area per cell. Mango flesh extracts from the three cultivars did not inhibit adipogenesis; peel extracts from both Irwin and Nam Doc Mai, however, did so with the Nam Doc Mai extract most potent at inhibiting adipogenesis. Peel extract from Kensington Pride promoted adipogenesis. The inhibition of adipogenesis by Irwin (100 μg mL(-1)) and Nam Doc Mai peel extracts (50 and 100 μg mL(-1)) was associated with an increase in the average nuclear area per cell; similar effects were seen with resveratrol, suggesting that these extracts may act through pathways similar to resveratrol. These results suggest that differences in the phytochemical composition between mango cultivars may influence their effectiveness in inhibiting adipogenesis, and points to mango fruit peel as a potential source of nutraceuticals.
Authors:
Meng-Wong Taing; Jean-Thomas Pierson; Van L T Hoang; Paul N Shaw; Ralf G Dietzgen; Michael J Gidley; Sarah J Roberts-Thomson; Gregory R Monteith
Related Documents :
1091617 - Regulation of methionine transport activity in escherichia coli.
20079367 - Protein kinase c isotypes in signal transduction for the 1,25d3-marrs receptor (erp57/p...
15313407 - Transport of resveratrol, a cancer chemopreventive agent, to cellular targets: plasmati...
8300557 - A leu-leu sequence is essential for cooh-terminal targeting signal of glut4 glucose tra...
23378817 - Termitotrox cupido sp. n. (coleoptera, scarabaeidae), a new termitophilous scarab speci...
11045257 - Effect of dialysate composition on the apoptosis and proliferation of human peritoneal ...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-06-15
Journal Detail:
Title:  Food & function     Volume:  3     ISSN:  2042-650X     ISO Abbreviation:  Food Funct     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-27     Completed Date:  2012-11-29     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  101549033     Medline TA:  Food Funct     Country:  England    
Other Details:
Languages:  eng     Pagination:  828-36     Citation Subset:  IM    
Affiliation:
School of Pharmacy, The University of Queensland, Queensland 4072, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
3T3-L1 Cells
Adipocytes / drug effects,  ultrastructure
Adipogenesis / drug effects*
Animals
Cell Nucleus / drug effects,  ultrastructure
Fruit / chemistry*
Mangifera / chemistry*
Mice
Plant Extracts / pharmacology*
Species Specificity
Stilbenes / pharmacology
Chemical
Reg. No./Substance:
0/Plant Extracts; 0/Stilbenes; Q369O8926L/resveratrol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Reaching Men Who Have Sex with Men in Myanmar: Population Characteristics, Risk and Preventive Behav...
Next Document:  Charge regulation in redox active monolayers embedded in proton exchanger surfaces.