Document Detail


Mangiferin - a bioactive xanthonoid, not only from mango and not just antioxidant.
MedLine Citation:
PMID:  23190031     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mangiferin is a plant natural polyphenol of C-glycosylxanthone structure and various pharmacological activities. It can be found in many plant species, among which the mango tree (Mangifera indica) is one of the primary sources. Mangiferin is also present in some medicinal herbs, influencing their therapeutic and preventive properties, and in honeybush (Cyclopia sp.), a popular South African herbal tea. Mangiferin dissolves well in water, so it can be easily extracted into infusions and decoctions. In the mangiferin molecule, four aromatic hydroxyl groups determine its strong antiradical and antioxidant properties. Mangiferin is also an efficient iron chelator, therefore preventing the generation of hydroxyl radical in Fenton-type reactions. Numerous published in vitro and in vivo pharmacological studies, demonstrated many other activities of mangiferin: analgesic, antidiabetic, antisclerotic, atimicrobial and antiviral, cardio-, hepato-, and neuroprotective, antiinflammatory, antiallergic, MAO inhibiting and memory improving, as well as radioprotective against X-ray, gamma, and UV radiation. Several studies indicated also its ability to inhibit cancerogenesis and cancer cells growth by apoptosis induction in vitro and in vivo. It is also used in cosmetics, due to antioxidant and UV-protecting properties.
Authors:
Adam Matkowski; Piotr Kuś; Edyta Góralska; Dorota Woźniak
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Mini reviews in medicinal chemistry     Volume:  13     ISSN:  1875-5607     ISO Abbreviation:  Mini Rev Med Chem     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-27     Completed Date:  2013-08-12     Revised Date:  2013-09-24    
Medline Journal Info:
Nlm Unique ID:  101094212     Medline TA:  Mini Rev Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  439-55     Citation Subset:  IM    
Affiliation:
Department Pharmaceutical Biology and Botany, Medical University of Wroclaw, Al. Jana Kochanowskiego 10, Wroclaw, Poland. pharmaceutical.biology@wp.eu
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / chemistry,  isolation & purification,  pharmacology*
Humans
Mangifera / chemistry*
Xanthones / chemistry,  isolation & purification,  pharmacology*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Xanthones; 1M84LD0UMD/mangiferin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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