| Manganese neurotoxicity and glutamate-GABA interaction. | |
| | |
MedLine Citation:
|
PMID: 12742094 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Brain extracellular concentrations of amino acids (e.g. aspartate, glutamate, taurine) and divalent metals (e.g. zinc, copper, manganese) are primarily regulated by astrocytes. Adequate glutamate homeostasis is essential for the normal functioning of the central nervous system (CNS). Glutamate is of central importance for nitrogen metabolism and, along with aspartate, is the primary mediator of the excitatory pathways in the brain. Similarly, the maintenance of proper manganese levels is important for normal brain functioning. Several in vivo and in vitro studies have linked increased manganese concentrations with alterations in the content and metabolism of neurotransmitters, namely dopamine, gamma-aminobutyric acid, and glutamate. It has been reported by our laboratory and others, that cultured rat primary astrocytes exposed to manganese displayed decreased glutamate uptake, thereby increasing the excitotoxic potential of glutamate. Furthermore, decreased uptake of glutamate has been associated with decreased gene expression of glutamate:aspartate transporter (GLAST) in manganese-exposed astroctyes. Additional studies have suggested that attenuation of astrocytic glutamate uptake by manganese may be a consequence of reactive oxygen species (ROS) generation. Collectively, these data suggest that excitotoxicity may occur due to manganese-induced altered glutamate metabolism, representing a proximate mechanism for manganese-induced neurotoxicity. |
| | |
Authors:
|
Keith M Erikson; Michael Aschner |
Related Documents
:
|
15749834 - D-glutamic acid-induced muscle contraction in the silkworm, bombyx mori. 1249054 - Avian mitochondrial glutamine metabolism. 1780024 - The structural and functional heterogeneity of glutamic acid decarboxylase: a review. 6643454 - Mathematical analysis of isotope labeling in the citric acid cycle with applications to... 937444 - Biological equivalence of ophthalmic prednisolone acetate suspensions. 1736904 - Peroxisomal fatty acid oxidation and inhibitors of the mitochondrial carnitine palmitoy... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Neurochemistry international Volume: 43 ISSN: 0197-0186 ISO Abbreviation: Neurochem. Int. Publication Date: 2003 Sep-Oct |
Date Detail:
|
Created Date: 2003-05-13 Completed Date: 2003-08-19 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 8006959 Medline TA: Neurochem Int Country: England |
Other Details:
|
Languages: eng Pagination: 475-80 Citation Subset: IM |
Affiliation:
|
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1083, USA. kerikson@wfubmc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Glutamic Acid / metabolism* Humans Manganese / pharmacology* gamma-Aminobutyric Acid / metabolism* |
| Chemical | |
Reg. No./Substance:
|
56-12-2/gamma-Aminobutyric Acid; 56-86-0/Glutamic Acid; 7439-96-5/Manganese |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Metabotropic glutamate receptors (mGluRs) are involved in early phase of memory formation: possible ...
Next Document: Role of group I metabotropic glutamate receptors and NMDA receptors in homocysteine-evoked acute neu...