| Manganese neurotoxicity: a focus on the neonate. | |
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MedLine Citation:
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PMID: 17084903 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Manganese (Mn) is an essential trace metal found in all tissues, and it is required for normal amino acid, lipid, protein, and carbohydrate metabolism. While Mn deficiency is extremely rare in humans, toxicity due to overexposure of Mn is more prevalent. The brain appears to be especially vulnerable. Mn neurotoxicity is most commonly associated with occupational exposure to aerosols or dusts that contain extremely high levels (>1-5 mg Mn/m(3)) of Mn, consumption of contaminated well water, or parenteral nutrition therapy in patients with liver disease or immature hepatic functioning such as the neonate. This review will focus primarily on the neurotoxicity of Mn in the neonate. We will discuss putative transporters of the metal in the neonatal brain and then focus on the implications of high Mn exposure to the neonate focusing on typical exposure modes (e.g., dietary and parenteral). Although Mn exposure via parenteral nutrition is uncommon in adults, in premature infants, it is more prevalent, so this mode of exposure becomes salient in this population. We will briefly review some of the mechanisms of Mn neurotoxicity and conclude with a discussion of ripe areas for research in this underreported area of neurotoxicity. |
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Authors:
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Keith M Erikson; Khristy Thompson; Judy Aschner; Michael Aschner |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2006-09-22 |
Journal Detail:
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Title: Pharmacology & therapeutics Volume: 113 ISSN: 0163-7258 ISO Abbreviation: Pharmacol. Ther. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-01-29 Completed Date: 2007-04-19 Revised Date: 2011-04-22 |
Medline Journal Info:
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Nlm Unique ID: 7905840 Medline TA: Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 369-77 Citation Subset: IM |
Affiliation:
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Department of Nutrition, University of North Carolina at Greensboro, Greensboro, NC, USA. kmerikso@uncg.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / metabolism Environmental Exposure Humans Infant, Newborn Manganese / metabolism, toxicity* Neurotoxicity Syndromes / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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10563//PHS HHS; R01 ES010563-01A1/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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7439-96-5/Manganese |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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