Document Detail

Manganese levels during pregnancy and at birth: relation to environmental factors and smoking in a Southwest Quebec population.
MedLine Citation:
PMID:  15147916     Owner:  NLM     Status:  MEDLINE    
Manganese (Mn) is both an essential element and a potent neurotoxin. Higher demand during pregnancy leads to increased blood levels. Previous studies have suggested that environmental factors may influence blood Mn levels. As part of a community-based survey of potentially toxic environmental contaminants among pregnant women, the objective of this exploratory study was to examine the Mn status in pregnant women and their newborns with respect to sociodemographic and environmental variables. Pregnant women from Southwest Quebec were recruited in the first or second trimester through the public health prenatal program Mn was analyzed in mother's blood at entry into the study, in the second trimester (for those who entered during the first trimester), and at delivery, as well as in umbilical cord blood and in placental tissue. Sociodemographic data and information about pregnancy were obtained by two questionnaires; the first was administered at study entry and the second a few weeks following birth. Results showed that mothers' Mn blood levels increased significantly during pregnancy and cord blood Mn levels were significantly higher than those for mothers' blood. There was no relation to age. Smokers had significantly lower Mn blood levels compared to nonsmokers at the second trimester. Those who lived in urban and/or agricultural areas had significantly higher levels compared to those who lived in small villages. Those who reported pesticide spraying less than 1 km from their house likewise had significantly higher levels compared to the others. These findings suggest that lifestyle and environmental factors may interfere with the delicate balance and homeostatic mechanisms required to maintain Mn at optimal levels for physiological changes during pregnancy.
Larissa Takser; Julie Lafond; Maryse Bouchard; Genevieve St-Amour; Donna Mergler
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental research     Volume:  95     ISSN:  0013-9351     ISO Abbreviation:  Environ. Res.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-18     Completed Date:  2004-07-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147621     Medline TA:  Environ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  119-25     Citation Subset:  IM    
CINBIOSE, Université DU Quebec à Montreal, C.P. 8888, Succ.Centre Ville, Montreal, Quebec H3C 3P8, Canada.
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MeSH Terms
Environmental Exposure
Fetal Blood / chemistry*
Infant, Newborn
Manganese / blood*
Smoking / adverse effects*
Reg. No./Substance:
0/Pesticides; 7439-96-5/Manganese

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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