Document Detail

Manganese in the air: are children at greater risk than adults?
MedLine Citation:
PMID:  20077285     Owner:  NLM     Status:  MEDLINE    
Whether or not children are at higher risk from exposure to air pollutants has become a central question in regulatory toxicology. In order to examine this issue for essential metals several questions related to toxicokinetics and toxicodynamics need to be addressed. These include (1) whether exposure patterns among infants and children are likely to result in disproportionately high exposures to substances in ambient air, and (2) whether infants display special susceptibilities in comparison to the general population. In addition, differences in how developing systems handle metals compared to adults, and interactions between specific metals and other substances with common mechanisms, need to be considered. This study examined the toxicodynamic differences between adults and infants exposed to manganese via inhalation and/or dietary routes of exposure.
Bruce S Winder
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of toxicology and environmental health. Part A     Volume:  73     ISSN:  1528-7394     ISO Abbreviation:  J. Toxicol. Environ. Health Part A     Publication Date:  2010  
Date Detail:
Created Date:  2010-01-15     Completed Date:  2010-02-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100960995     Medline TA:  J Toxicol Environ Health A     Country:  England    
Other Details:
Languages:  eng     Pagination:  156-8     Citation Subset:  IM    
Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Sacramento, California, USA.
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MeSH Terms
Age Distribution*
Air Pollutants / adverse effects*,  pharmacokinetics
Child, Preschool
Environmental Exposure
Infant, Newborn
Inhalation Exposure
Manganese / adverse effects*,  pharmacokinetics
Middle Aged
Risk Assessment
Young Adult
Reg. No./Substance:
0/Air Pollutants; 7439-96-5/Manganese

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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