Document Detail


Manganese-enhanced MRI of rat spinal cord injury.
MedLine Citation:
PMID:  16214614     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The potential of the manganese-enhanced MRI (MEI) technique in labeling the intact neuronal circuitry of rat spinal cord was examined. Experiments were conducted on normal and injured cords at 9.4-T magnetic field strength using an implantable rf coil. The contrast agent manganese (Mn) was locally delivered within the parenchyma at a dose of 25 mmol/L in 10 nL. The transport, uptake and accumulation of Mn in tissue were then followed remotely on T1-weighted images that were acquired serially from the cord. In MEIs of normal cord, Mn was observed to be transported in directions both rostral and caudal to the site of injection. In the cord that was subjected to hemisection, signal enhancement was on the contralesional side of the cord, but not at the ipsilesional side. The sensitivity and specificity of the MEI technique in labeling the neurons that are functional were also validated with a traditional track-tracing method using biotinylated dextran amine.
Authors:
Mehmet Bilgen; Numa Dancause; Baraa Al-Hafez; Yong-Yue He; Thomas M Malone
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Publication Detail:
Type:  Journal Article     Date:  2005-08-29
Journal Detail:
Title:  Magnetic resonance imaging     Volume:  23     ISSN:  0730-725X     ISO Abbreviation:  Magn Reson Imaging     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-10-10     Completed Date:  2006-05-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214883     Medline TA:  Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  829-32     Citation Subset:  IM    
Affiliation:
Hoglund Brain Imaging Center, The University of Kansas Medical Center, Kansas City, KS 66160, USA. mbilgen@kumc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Contrast Media / pharmacokinetics
Magnetic Resonance Imaging / methods*
Manganese / diagnostic use*,  pharmacokinetics
Rats
Sensitivity and Specificity
Spinal Cord Injuries / pathology*
Chemical
Reg. No./Substance:
0/Contrast Media; 7439-96-5/Manganese

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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