Document Detail

Manganese-bilirubin cholestasis. Further studies in pathogenesis.
MedLine Citation:
PMID:  3807313     Owner:  NLM     Status:  MEDLINE    
To further delineate the mechanism of manganese-bilirubin cholestasis, studies were done to determine: the structural status of the canalicular tight junctions in the model, and the effect of the lack of bilirubin conjugation. The results indicate that canalicular tight junction alterations characteristic of many types of cholestasis develop in this model and that bilirubin conjugation is not a requisite for the cholestatic effect of bilirubin to occur. It is unclear whether the tight junction alterations are the cause of the cholestasis or either secondary effects of the cholestasis or associated noncausal occurrences. The fact that bilirubin does not need to be conjugated in order to effect cholestasis confirms that the cholestasis is due to intrahepatocytic (as opposed to intracanalicular) effects, and may be useful in determining the precise locus and nature of these effects.
C L Witzleben; J L Boyer; O C Ng
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Laboratory investigation; a journal of technical methods and pathology     Volume:  56     ISSN:  0023-6837     ISO Abbreviation:  Lab. Invest.     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-03-26     Completed Date:  1987-03-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376617     Medline TA:  Lab Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  151-4     Citation Subset:  IM    
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MeSH Terms
Cholestasis / chemically induced,  pathology*
Freeze Fracturing
Gallbladder / ultrastructure
Intercellular Junctions / ultrastructure
Microscopy, Electron
Rats, Gunn
Rats, Inbred Strains
Grant Support
Reg. No./Substance:
635-65-4/Bilirubin; 7439-96-5/Manganese

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