| Manganese-based MRI contrast agents: past, present and future. | |
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MedLine Citation:
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PMID: 22043109 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Paramagnetic and superparamagnetic metals are used as contrast materials for magnetic resonance (MR) based techniques. Lanthanide metal gadolinium (Gd) has been the most widely explored, predominant paramagnetic contrast agent until the discovery and association of the metal with nephrogenic systemic fibrosis (NSF), a rare but serious side effects in patients with renal or kidney problems. Manganese was one of the earliest reported examples of paramagnetic contrast material for MRI because of its efficient positive contrast enhancement. In this review, manganese based contrast agent approaches are discussed with a particular emphasis on their synthetic approaches. Both small molecules based typical blood pool contrast agents and more recently developed novel nanometer sized materials are reviewed focusing on a number of successful molecular imaging examples. |
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Authors:
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Dipanjan Pan; Anne H Schmieder; Samuel A Wickline; Gregory M Lanza |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Tetrahedron Volume: 67 ISSN: 0040-4020 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2984170R Medline TA: Tetrahedron Country: - |
Other Details:
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Languages: ENG Pagination: 8431-8444 Citation Subset: - |
Affiliation:
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Division of Cardiology and C-TRAIN, Washington University School of Medicine, St. Louis, MO 63108 USA. |
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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R01 CA154737-01A1//NCI NIH HHS; R01 HL094470-01A1//NHLBI NIH HHS; R01 NS059302-05//NINDS NIH HHS |
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