| Manganese absorption in humans: the effect of phytic acid and ascorbic acid in soy formula. | |
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MedLine Citation:
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PMID: 7572746 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The absorption of manganese from soy formula was studied in adult volunteers by extrinsic labeling of test meals with 54Mn, followed by whole-body retention measurements for approximately 30 d after intake. Eight subjects participated twice in each of the two studies, acting as his or her own control. Soy formula containing the native content of phytic acid was compared with a similar dephytinized formula: geometric mean manganese absorption increased 2.3-fold from 0.7% (range: 0.2-1.1%) to 1.6% (range: 1.0-7.2%) (P < 0.01) with the dephytinized formula. In addition, the effect of the ascorbic acid content of the phytic acid-containing formula was investigated. Manganese absorption was not influenced by an increase in the ascorbic acid from 625 mumol/L (110 mg/L) to 1250 mumol/L (220 mg/L): the geometric mean manganese absorption was 0.6% (range: 0.3-1.0%) and 0.6% (range: 0.3-1.1%), respectively. In conclusion, fractional manganese absorption was approximately doubled by the dephytinization of soy formula but was not influenced by an increase in the ascorbic acid content of a soy formula containing the native amount of phytic acid. |
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Authors:
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L Davidsson; A Almgren; M A Juillerat; R F Hurrell |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 62 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1995 Nov |
Date Detail:
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Created Date: 1995-11-22 Completed Date: 1995-11-22 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 984-7 Citation Subset: AIM; IM |
Affiliation:
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Nestlé Research Centre, Lausanne, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Ascorbic Acid / pharmacology* Biological Availability Dietary Proteins / metabolism Female Food, Formulated Humans Intestinal Absorption* / drug effects Intestine, Small / metabolism* Iron / pharmacokinetics Male Manganese / pharmacokinetics* Phytic Acid / pharmacology* Radioisotopes Soybean Proteins Vegetable Proteins / drug effects, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Proteins; 0/Radioisotopes; 0/Soybean Proteins; 0/Vegetable Proteins; 50-81-7/Ascorbic Acid; 7439-89-6/Iron; 7439-96-5/Manganese; 83-86-3/Phytic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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