| Mandibular deformities in parathyroid hormone-related protein (PTHrP) deficient mice: possible involvement of masseter muscle. | |
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MedLine Citation:
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PMID: 10985428 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies using parathyroid hormone-related protein (PTHrP) null mutant mice have indicated severe abnormalities in the endochondral ossification, suggesting that PTHrP affects chondrocyte differentiation. In this study, we found in newborn PTHrP-deficient mice some deformities in the mandible that is formed via intramembranous ossification. The mandibular ramus was bent downwards and a prominent bone crest to which the deep layer of masseter muscle was tendinously attached was observed in the mandibular body. Transmission electron microscopic studies showed that active bone formation was progressing along the tendon fibers of the masseter muscle. The examination of 3-D reconstruction models indicated that the mandibular ramus was bent at the site of muscle attachment, which was shifted in the direction of the muscle fibers. Muscle fiber type analysis using myosin ATPase staining showed that the masseter muscle in the newborn PTHrP-deficient mice contained numerous type 2B fibers, demonstrating premature maturation of this muscle. Based on these findings, we speculated that premature maturation of the masseter muscle leads, probably due to increased tensile forces, to accelerated bone crest formation and subsequent bending of the mandibular ramus. These results further suggest that PTHrP is involved in the regulation of muscle development in normal animals. |
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Authors:
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S Shibata; N Suda; K Yamazaki; T Kuroda; F Beck; P V Senior; V E Hammond |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anatomy and embryology Volume: 202 ISSN: 0340-2061 ISO Abbreviation: Anat. Embryol. Publication Date: 2000 Aug |
Date Detail:
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Created Date: 2000-12-13 Completed Date: 2000-12-28 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7505194 Medline TA: Anat Embryol (Berl) Country: GERMANY |
Other Details:
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Languages: eng Pagination: 85-93 Citation Subset: IM |
Affiliation:
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Department of Maxillofacial Anatomy, Graduate School, Tokyo Medical and Dental University, Japan. S.Shibata.oan1@dent.tmd.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Gestational Age Immunohistochemistry Mandible / abnormalities* Masseter Muscle / chemistry, embryology, ultrastructure Mice Mice, Knockout Microscopy, Electron Muscle Fibers, Skeletal / chemistry, ultrastructure Myosins / analysis Parathyroid Hormone-Related Protein Proteins / analysis, genetics, physiology* Receptor, Parathyroid Hormone, Type 1 Receptors, Parathyroid Hormone / analysis |
| Chemical | |
Reg. No./Substance:
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0/Parathyroid Hormone-Related Protein; 0/Proteins; 0/Receptor, Parathyroid Hormone, Type 1; 0/Receptors, Parathyroid Hormone; EC 3.6.4.1/Myosins |
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