| The mandatory role of IL-10-producing and OX40 ligand-expressing mature Langerhans cells in local UVB-induced immunosuppression. | |
| | |
MedLine Citation:
|
PMID: 20400709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The mechanism underlying the local UVB-induced immunosuppression is a central issue to be clarified in photoimmunology. There have been reported a considerable number of cells and factors that participate in the sensitization phase-dependent suppression, including Langerhans cells (LCs), regulatory T cells, IL-10, and TNF-alpha. The recent important finding that LC-depleted mice rather exhibit enhanced contact hypersensitivity responses urged us to re-evaluate the role of LCs along with dermal dendritic cells (dDCs) in the mechanism of UVB-induced immunosuppression. We studied the surface expression of OX40 ligand (OX40L) and the intracellular expression of IL-10 in LCs and dDCs from UVB-irradiated (300 mJ/cm(2)) skin of BALB/c mice and those migrating to the regional lymph nodes from UVB-irradiated, hapten-painted mice. In epidermal and dermal cell suspensions prepared from the UVB-irradiated skin, LCs expressed OX40L as well as CD86 and produced IL-10 at a higher level than Langerin(-) dDCs. The UVB-induced immunosuppression was attenuated by the administration of IL-10-neutralizing or OX40L-blocking Abs. In mice whose UVB-irradiated, hapten-painted skin was dissected 1 d after hapten application, the contact hypersensitivity response was restored, because this treatment allowed dDCs but not LCs to migrate to the draining lymph nodes. Moreover, LC-depleted mice by using Langerin-diphtheria toxin receptor-knocked-in mice showed impaired UVB-induced immunosuppression. These results suggest that IL-10-producing and OX40L-expressing LCs in the UVB-exposed skin are mandatory for the induction of Ag-specific regulatory T cells. |
| | |
Authors:
|
Ryutaro Yoshiki; Kenji Kabashima; Jun-ichi Sakabe; Kazunari Sugita; Toshinori Bito; Motonobu Nakamura; Bernard Malissen; Yoshiki Tokura |
Related Documents
:
|
15816159 - Seroepidemiology of borrelia burgdorferi sensu lato and anaplasma phagocytophilum in wi... 18799709 - Ligand activation of peroxisome proliferator-activated receptor beta/delta (ppar beta/d... 10641599 - An in vivo model of human skin acute graft-versus-host disease: transplantation of cult... 12890429 - Oral administration of royal jelly inhibits the development of atopic dermatitis-like s... 661009 - Comparative studies on effects of incomplete oil adjuvants with different physical prop... 2004349 - Carcinogenicity study of fecapentaene-12 diacetate on skin painting in sencar mice. 21093029 - Single-tree nut immunotherapy attenuates allergic reactions in mice with hypersensitivi... 18668149 - Lipopolysaccharide preconditioning induces protection against lipopolysaccharide-induce... 7680639 - Heterogeneity in localization of isoforms of tgf-beta in human retina, vitreous, and ch... |
Publication Detail:
|
Type: Journal Article Date: 2010-04-16 |
Journal Detail:
|
Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 184 ISSN: 1550-6606 ISO Abbreviation: J. Immunol. Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-05-20 Completed Date: 2010-07-19 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
|
Languages: eng Pagination: 5670-7 Citation Subset: AIM; IM |
Affiliation:
|
Department of Dermatology, University of Occupational and Environmental Health, Fukuoka, Japan. yockey@med.uoeh-u.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antigens, Surface / genetics Cell Differentiation / immunology*, radiation effects Female Gene Knock-In Techniques Immunosuppression* / methods Intercellular Signaling Peptides and Proteins / genetics Interleukin-10 / biosynthesis*, radiation effects Langerhans Cells / immunology*, metabolism, radiation effects Lectins, C-Type / genetics Ligands Lymphocyte Activation / immunology, radiation effects Mannose-Binding Lectins / genetics Membrane Glycoproteins / biosynthesis*, radiation effects Mice Mice, Inbred BALB C Organ Culture Techniques Skin / cytology, immunology, radiation effects T-Lymphocytes, Regulatory / immunology, metabolism, radiation effects Tumor Necrosis Factors / biosynthesis*, radiation effects Ultraviolet Rays* |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, Surface; 0/Cd207 protein, mouse; 0/Intercellular Signaling Peptides and Proteins; 0/Lectins, C-Type; 0/Ligands; 0/Mannose-Binding Lectins; 0/Membrane Glycoproteins; 0/Tnfsf4 protein, mouse; 0/Tumor Necrosis Factors; 130068-27-8/Interleukin-10; 149176-25-0/heparin-binding EGF-like growth factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: TCR stimulation drives cleavage and shedding of the ITIM receptor CD31.
Next Document: The isoenergetic brain: the idea and some implications.