Document Detail


Managing tricyclic antidepressant overdose.
MedLine Citation:
PMID:  1621627     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tricyclic antidepressant overdose is the most common cause of death from prescription drugs. Clinical presentation of overdose from the tricyclic agents includes cardiac arrhythmias, hypotension, seizures, coma and anticholinergic signs such as hyperthermia, flushing and intestinal ileus. The highly toxic/lethal level (greater than 1,000 ng per mL) is manifested on electrocardiograms as prolongation of the QRS interval to 100 milliseconds or more. Treatment includes establishment of an airway, proper oxygenation and ventilation, fluid replacement at maintenance levels, cardiac monitoring, gastric lavage and charcoal administration, alkalinization to a blood pH of 7.5 with intravenous sodium bicarbonate, supportive therapy and continued cardiac monitoring after clinical recovery.
Authors:
L M Haddad
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American family physician     Volume:  46     ISSN:  0002-838X     ISO Abbreviation:  Am Fam Physician     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-08-03     Completed Date:  1992-08-03     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  1272646     Medline TA:  Am Fam Physician     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  153-9     Citation Subset:  AIM; IM    
Affiliation:
Medical University of South Carolina College of Medicine, Charleston.
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MeSH Terms
Descriptor/Qualifier:
Antidepressive Agents, Tricyclic / pharmacokinetics,  poisoning*
Humans
Overdose
Poisoning / therapy
Chemical
Reg. No./Substance:
0/Antidepressive Agents, Tricyclic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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