Document Detail

Managing tricyclic antidepressant overdose.
MedLine Citation:
PMID:  1621627     Owner:  NLM     Status:  MEDLINE    
Tricyclic antidepressant overdose is the most common cause of death from prescription drugs. Clinical presentation of overdose from the tricyclic agents includes cardiac arrhythmias, hypotension, seizures, coma and anticholinergic signs such as hyperthermia, flushing and intestinal ileus. The highly toxic/lethal level (greater than 1,000 ng per mL) is manifested on electrocardiograms as prolongation of the QRS interval to 100 milliseconds or more. Treatment includes establishment of an airway, proper oxygenation and ventilation, fluid replacement at maintenance levels, cardiac monitoring, gastric lavage and charcoal administration, alkalinization to a blood pH of 7.5 with intravenous sodium bicarbonate, supportive therapy and continued cardiac monitoring after clinical recovery.
L M Haddad
Related Documents :
16040667 - A randomized clinical trial of activated charcoal for the routine management of oral dr...
1538857 - Wellington coroner autopsy cases 1970-89: acute deaths due to drugs, alcohol and poisons.
12678297 - Ten years of latrogenic intoxications from the spanish poison control center.
9460217 - Lead poisoning and parasitism in a flock of mute swans (cygnus olor) in scotland.
15737247 - The inhalation of drugs: advantages and problems.
2201517 - Opioids and designer drugs.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American family physician     Volume:  46     ISSN:  0002-838X     ISO Abbreviation:  Am Fam Physician     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-08-03     Completed Date:  1992-08-03     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  1272646     Medline TA:  Am Fam Physician     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  153-9     Citation Subset:  AIM; IM    
Medical University of South Carolina College of Medicine, Charleston.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antidepressive Agents, Tricyclic / pharmacokinetics,  poisoning*
Poisoning / therapy
Reg. No./Substance:
0/Antidepressive Agents, Tricyclic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Temporomandibular joint disorder.
Next Document:  Common skin tumors in the elderly.