| Managing membrane stress: the phage shock protein (Psp) response, from molecular mechanisms to physiology. | |
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MedLine Citation:
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PMID: 20636484 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The bacterial phage shock protein (Psp) response functions to help cells manage the impacts of agents impairing cell membrane function. The system has relevance to biotechnology and to medicine. Originally discovered in Escherichia coli, Psp proteins and homologues are found in Gram-positive and Gram-negative bacteria, in archaea and in plants. Study of the E. coli and Yersinia enterocolitica Psp systems provides insights into how membrane-associated sensory Psp proteins might perceive membrane stress, signal to the transcription apparatus and use an ATP-hydrolysing transcription activator to produce effector proteins to overcome the stress. Progress in understanding the mechanism of signal transduction by the membrane-bound Psp proteins, regulation of the psp gene-specific transcription activator and the cell biology of the system is presented and discussed. Many features of the action of the Psp system appear to be dominated by states of self-association of the master effector, PspA, and the transcription activator, PspF, alongside a signalling pathway that displays strong conditionality in its requirement. |
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Authors:
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Nicolas Joly; Christoph Engl; Goran Jovanovic; Maxime Huvet; Tina Toni; Xia Sheng; Michael P H Stumpf; Martin Buck |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-06-09 |
Journal Detail:
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Title: FEMS microbiology reviews Volume: 34 ISSN: 1574-6976 ISO Abbreviation: FEMS Microbiol. Rev. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-11 Completed Date: 2011-01-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8902526 Medline TA: FEMS Microbiol Rev Country: England |
Other Details:
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Languages: eng Pagination: 797-827 Citation Subset: IM |
Affiliation:
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Division of Biology, Imperial College London, South Kensington, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Physiological Phenomena* Bacterial Proteins / metabolism* Cell Membrane / metabolism* Escherichia coli / physiology Escherichia coli Proteins / chemistry, metabolism Heat-Shock Proteins / metabolism* Membrane Proteins / metabolism* Signal Transduction Stress, Physiological* Trans-Activators / chemistry, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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//Biotechnology and Biological Sciences Research Council; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/Escherichia coli Proteins; 0/Heat-Shock Proteins; 0/Membrane Proteins; 0/PspF protein, E coli; 0/Trans-Activators; 0/phage shock protein, Bacteria |
| Comments/Corrections | |
Comment In:
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FEMS Microbiol Rev. 2010 Sep;34(5):611-27
[PMID:
20678145
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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