| Managing Epilepsy During Pregnancy: Assessing Risk and Optimizing Care. | |
| | |
MedLine Citation:
|
PMID: 22711429 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OPINION STATEMENT: Epilepsy is the most common neurologic condition found in pregnancy. As such, all neurologists, internists, and obstetricians should know how to counsel women with epilepsy as they are considering pregnancy. While all of the usual recommendations for women of childbearing potential apply, including preconceptual and ongoing use of folic acid, calcium, and vitamin D, additional consideration must be given to the need for adjustment or change of anticonvulsant therapy. Monotherapy with the lowest dose of medication needed to control seizures should be prescribed prior to conception. Most anticonvulsants have a favorable profile when used in pregnancy; older anticonvulsants such as valproate and carbamazepine should be avoided, as they are associated with higher rates of fetal malformation, and in the case of valproate, with proven cognitive deficits in children exposed to this medication in utero. With use of any anticonvulsant medication, dosing throughout pregnancy will need to be adjusted to maintain an appropriate serum concentration. Dosing of anticonvulsants needs to be decreased after delivery to avoid medication-related toxicity, although sleep deprivation and hormonal fluctuation can increase the risk of seizures in postpartum women. With proper management, the majority of women with epilepsy can have uneventful pregnancies and healthy babies. |
| | |
Authors:
|
Kaarkuzhali Babu Krishnamurthy |
Related Documents
:
|
1554259 - Toxicity of construction materials in the marine environment: a comparison of chromated... 17499709 - Pregnancy and vasculitis. 6689839 - Maternal age and overdue conceptions. 22519389 - Intraamniotic inflammatory response to bacteria: analysis of multiple amniotic fluid pr... 21673209 - Safety of skin care products during pregnancy. 22397179 - Termination of pregnancy under french law: from criminalization to a right in accordanc... 2959179 - Oocyte retrieval for in vitro fertilization. 20354149 - Expression of aryl hydrocarbon receptor in human placentas and fetal tissues. 2363199 - Aetiological factors in low birth weight in a nigerian population. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-6-19 |
Journal Detail:
|
Title: Current treatment options in neurology Volume: - ISSN: 1534-3138 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
|
Created Date: 2012-6-19 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9815940 Medline TA: Curr Treat Options Neurol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Women's Health in Epilepsy, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA, bkrishna@bidmc.harvard.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Oxytocin interference in the effects induced by inhalation of 7.5% CO(2) in healthy volunteers.
Next Document: Unusual case of coronary perforation which developed delayed cardiac tamponade due to collateral flo...