Document Detail


Management of voltage-gated potassium channel antibody disorders.
MedLine Citation:
PMID:  20816272     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Syndromes from antibodies to voltage-gated potassium channels include neuromyotonia (NMT), limbic encephalitis (LE) and Morvan syndrome (MVS). There are distinct clinical features for NMT (cramps, stiffness, fasciculations, myokymia, hyperhidrosis; afterdischarges and continuous motor activity on electromyogram), LE (encephalopathy with seizures, deficient recent memory; hyponatremia, temporal lobe magnetic resonance imaging and electroencephalographic abnormalities) and MVS (NMT plus hyperhidrosis, dysautonomia, encephalopathy, severe insomnia, and sleep disorders). There may be associated myasthenia gravis or thymoma, and rarely lung cancer (small cell or adenocarcinoma), mandating that chest imaging be part of the evaluation. Most cases respond favorably to immunosuppression with plasma exchange, intravenous immunoglobulin or pulse intravenous methylprednisolone, usually followed by oral steroids.
Authors:
Michael P Merchut
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neurologic clinics     Volume:  28     ISSN:  1557-9875     ISO Abbreviation:  Neurol Clin     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-09-06     Completed Date:  2011-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8219232     Medline TA:  Neurol Clin     Country:  United States    
Other Details:
Languages:  eng     Pagination:  941-59     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Neurology, Stritch School of Medicine, Loyola University Chicago, Building 105, Room 2720, 2160 South First Avenue, Maywood, IL 60153, USA. mmerchu@lumc.edu
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MeSH Terms
Descriptor/Qualifier:
Glucocorticoids / therapeutic use
Humans
Immunoglobulins, Intravenous / therapeutic use
Immunosuppression
Isaacs Syndrome / immunology,  therapy*
Limbic Encephalitis / immunology,  therapy*
Methylprednisolone / therapeutic use
Plasma Exchange
Potassium Channels / immunology*
Syringomyelia / immunology,  therapy*
Chemical
Reg. No./Substance:
0/Glucocorticoids; 0/Immunoglobulins, Intravenous; 0/Potassium Channels; 83-43-2/Methylprednisolone

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