| Management of voltage-gated potassium channel antibody disorders. | |
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MedLine Citation:
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PMID: 20816272 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Syndromes from antibodies to voltage-gated potassium channels include neuromyotonia (NMT), limbic encephalitis (LE) and Morvan syndrome (MVS). There are distinct clinical features for NMT (cramps, stiffness, fasciculations, myokymia, hyperhidrosis; afterdischarges and continuous motor activity on electromyogram), LE (encephalopathy with seizures, deficient recent memory; hyponatremia, temporal lobe magnetic resonance imaging and electroencephalographic abnormalities) and MVS (NMT plus hyperhidrosis, dysautonomia, encephalopathy, severe insomnia, and sleep disorders). There may be associated myasthenia gravis or thymoma, and rarely lung cancer (small cell or adenocarcinoma), mandating that chest imaging be part of the evaluation. Most cases respond favorably to immunosuppression with plasma exchange, intravenous immunoglobulin or pulse intravenous methylprednisolone, usually followed by oral steroids. |
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Authors:
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Michael P Merchut |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Neurologic clinics Volume: 28 ISSN: 1557-9875 ISO Abbreviation: Neurol Clin Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-09-06 Completed Date: 2011-01-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8219232 Medline TA: Neurol Clin Country: United States |
Other Details:
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Languages: eng Pagination: 941-59 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Neurology, Stritch School of Medicine, Loyola University Chicago, Building 105, Room 2720, 2160 South First Avenue, Maywood, IL 60153, USA. mmerchu@lumc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Glucocorticoids
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therapeutic use Humans Immunoglobulins, Intravenous / therapeutic use Immunosuppression Isaacs Syndrome / immunology, therapy* Limbic Encephalitis / immunology, therapy* Methylprednisolone / therapeutic use Plasma Exchange Potassium Channels / immunology* Syringomyelia / immunology, therapy* |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Immunoglobulins, Intravenous; 0/Potassium Channels; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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