Document Detail

Management of ventriculomegaly in the fetus.
MedLine Citation:
PMID:  6737155     Owner:  NLM     Status:  MEDLINE    
We studied 24 human fetuses with cerebral ventriculomegaly by serial obstetric ultrasound to define the natural history of fetal ventricular enlargement and to develop a management strategy. In 10 fetuses, ventriculomegaly was associated with other severe anomalies; nine of these families chose to terminate the pregnancy. In three other severely affected fetuses in whom ventriculomegaly was detected serendipitously late in gestation, routine obstetrical management was performed; none survived. Eleven fetuses had ventriculomegaly without associated severe anomalies. Ventriculomegaly remained stable or of moderate severity throughout gestation in nine, resolved gradually in one, and progressed in one who did not have signs of increased intracranial pressure at birth. All of these fetuses were viable; three patients required shunting in the neonatal period, and two others by 5 months of age. Although obstetric ultrasound usually can detect anomalies associated with fetal ventriculomegaly, three fetuses with isolated ventriculomegaly had midline brain malformations that could not be distinguished in utero from hydrocephalus, even in retrospect. Prenatal diagnosis improves perinatal management by allowing counseling, and selective pregnancy termination, or selection of the timing, mode, and place of delivery to optimize outcome. Most fetuses with ventriculomegaly do not require intervention before birth.
P L Glick; M R Harrison; D K Nakayama; M S Edwards; R A Filly; D H Chinn; P W Callen; S L Wilson; M S Golbus
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  105     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-08-20     Completed Date:  1984-08-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  97-105     Citation Subset:  AIM; IM    
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MeSH Terms
Abnormalities, Multiple / complications,  diagnosis
Delivery, Obstetric
Fetal Diseases / diagnosis*
Hydrocephalus / congenital,  diagnosis*
Infant, Newborn
Intracranial Pressure
Prenatal Diagnosis
Tomography, X-Ray Computed

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