Document Detail

Management of varicella-zoster contact and infection in pregnancy using a standardized varicella-zoster ELISA test.
MedLine Citation:
PMID:  3014475     Owner:  NLM     Status:  MEDLINE    
An ongoing 5-year prospective study of the outcome of contact with varicella-zoster virus (VZV) and infection in pregnant women has made use of a standardized VZV enzyme-linked immunosorbent assay for the determination of immune status and as a guide for therapeutic management. Out of of a total of 778 such cases investigated to date in the Federal Republic of Germany, 93.1% have been shown to be VZV immune, whereas 6.9% were seronegative and, therefore, susceptible to infection. Those of the latter group who received zoster hyperimmunoglobulin (ZIG) between 24-96 hours after varicella contact remained symptom-free, while women receiving ZIG from the 3rd-10th day after contact developed a modified varicella. For the prevention of varicella, ZIG with known titres should be administered at doses of 0.2-0.4 ml/kg. It is also recommended for the newborn when maternal infection occurs within 4 days before until 2-4 days after delivery. The prevention and attenuation of varicella in pregnancy is justified since the outcomes may include spontaneous abortion in early pregnancy, the congenital varicella syndrome, and severe neonatal disease with a rather high mortality around term.
G Enders
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Postgraduate medical journal     Volume:  61 Suppl 4     ISSN:  0032-5473     ISO Abbreviation:  Postgrad Med J     Publication Date:  1985  
Date Detail:
Created Date:  1986-07-25     Completed Date:  1986-07-25     Revised Date:  2009-10-22    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  23-30     Citation Subset:  IM    
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MeSH Terms
Abortion, Spontaneous / etiology
Antibodies, Viral / isolation & purification
Chickenpox / diagnosis*,  prevention & control,  transmission
Enzyme-Linked Immunosorbent Assay
Herpes Zoster / diagnosis*
Herpesvirus 3, Human / immunology
Immune Sera*
Immunization, Passive
Immunoglobulin G
Pregnancy Complications, Infectious / diagnosis*
Prospective Studies
Reg. No./Substance:
0/Antibodies, Viral; 0/Immune Sera; 0/Immunoglobulin G; 0/varicella-zoster immune globulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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