Document Detail

Management of uterine hyperstimulation with concomitant use of oxytocin and terbutaline.
MedLine Citation:
PMID:  16847795     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to evaluate the efficacy of the concomitant use of subcutaneous terbutaline and oxytocin for the management of uterine hyperstimulation. Patients in active labor receiving intravenous oxytocin who developed uterine hyperstimulation were randomly assigned to receive either oxytocin discontinuation or administration of subcutaneous terbutaline while maintaining the oxytocin infusion. Time to resolution of hyperstimulation was the primary end point. Twenty-nine patients were enrolled. The most frequent types of hyperstimulation were tachysystole (26%) and mixed patterns (26%). Resolution time was significantly shorter in the combination therapy versus control ( P = 0.002). Persistence of hyperstimulation 15 minutes after intervention was seen in 53% of the women in the control group versus 0% of the women in the study group. No significant differences were noted in the Apgar scores, rates of cesarean sections, or chorioamnionitis. In the management of uterine hyperstimulation, subcutaneous terbutaline without discontinuation of oxytocin is more effective than the traditional approach of oxytocin discontinuation.
Luis D Pacheco; Mitchell P Rosen; Alfredo F Gei; George R Saade; Gary D V Hankins
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2006-07-17
Journal Detail:
Title:  American journal of perinatology     Volume:  23     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-14     Completed Date:  2006-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  377-80     Citation Subset:  IM    
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas 77555, USA.
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MeSH Terms
Drug Therapy, Combination
Infant, Newborn
Infusions, Intravenous
Injections, Subcutaneous
Labor, Induced*
Oxytocin / administration & dosage*
Pregnancy Outcome
Terbutaline / administration & dosage*
Tocolytic Agents / administration & dosage*
Treatment Outcome
Uterine Contraction / drug effects*
Reg. No./Substance:
0/Tocolytic Agents; 23031-25-6/Terbutaline; 50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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