Document Detail


Management of trauma-induced coagulopathy: trends and practices.
MedLine Citation:
PMID:  20977127     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nearly one-fourth of all trauma admissions present in varying degrees of coagulopathy. According to a US study, 40% of trauma fatalities are due to hemorrhage and hemorrhagic shock, and nearly all patients who are alive when they reach the hospital are coagulopathic when they die. Once coagulopathy develops, patient morbidity drastically increases. Because of the clinical significance of trauma-induced coagulopathy, management strategies to reduce the morbidity and mortality have recently become of interest. This article will review the pathology of trauma-induced coagulopathy and current trends in management, as well as closely examine the data surrounding the use of recombinant factor VII for the treatment of trauma-induced coagulopathy.
Authors:
Matthew R D'Angelo; Richard P Dutton
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  AANA journal     Volume:  78     ISSN:  0094-6354     ISO Abbreviation:  AANA J     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-10-27     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0431420     Medline TA:  AANA J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  35-40     Citation Subset:  N    
Affiliation:
R Adams Cowley Shock Trauma Center, Division of Trauma Amesthesiology, University of Maryland Medical Center, Baltimore, Maryland, USA. mdangelo@umaryland.edu
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MeSH Terms
Descriptor/Qualifier:
Acidosis / complications
Blood Coagulation Disorders / drug therapy*,  etiology*,  physiopathology
Brain Injuries / complications
Factor VIIa / therapeutic use*
Fever / complications
Fluid Therapy / adverse effects
Humans
Off-Label Use
Recombinant Proteins / therapeutic use
Shock, Hemorrhagic / complications
Wounds and Injuries / complications*
Chemical
Reg. No./Substance:
0/Recombinant Proteins; 0/recombinant FVIIa; EC 3.4.21.21/Factor VIIa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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