Document Detail

Management of thrombosis in peripheral arterial disease.
MedLine Citation:
PMID:  7804739     Owner:  NLM     Status:  MEDLINE    
There is accumulating evidence that thrombosis contributes to peripheral arterial disease, and that antithrombotic therapy should be considered at all symptomatic stages. In claudication, antiplatelet therapy is indicated in addition to lifestyle advice and sometimes surgery or angioplasty; the place of thrombolysis is unproven. In chronic critical limb ischaemia, prophylaxis of venous thromboembolism by low-dose heparin is indicated during hospitalisation, as is long-term antiplatelet therapy; local thrombolysis or systemic prostanoid infusions are increasingly used. In acute critical limb ischaemia, full dose heparinisation is followed by thromboembolectomy, local thrombolysis, angioplasty and surgery as appropriate. Antiplatelet therapy and/or anticoagulation are employed following such procedures, according to risk factors in the individual patient. Collaboration between vascular surgeons, radiologists and physicians is important in comprehensive patient care.
G D Lowe; A W Reid; D P Leiberman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  British medical bulletin     Volume:  50     ISSN:  0007-1420     ISO Abbreviation:  Br. Med. Bull.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-01-30     Completed Date:  1995-01-30     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0376542     Medline TA:  Br Med Bull     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  923-35     Citation Subset:  IM    
University Department of Medicine, Department of Radiology, Glasgow Royal Infirmary, UK.
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MeSH Terms
Arm / blood supply
Intermittent Claudication / drug therapy
Ischemia / drug therapy
Leg / blood supply
Peripheral Vascular Diseases / drug therapy*
Thrombolytic Therapy / methods*
Thrombosis / complications,  drug therapy*

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