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Management of third stage of labor with misoprostol: A comparison of three routes of administration.
MedLine Citation:
PMID:  23125961     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND CONTEXT: Misoprostol is a versatile drug with an effective uterotonic effect on the postpartum uterine tissue and is used through various routes during the third stage of labor.
AIMS AND OBJECTIVES: A randomized prospective study was carried out to analyze the most effective route for misoprostol administration, with an emphasis on parturients' acceptability and compliance, a possible shortening of the duration of the third stage of labor, minimization of blood loss and possibly reducing the incidence of potential side effects.
MATERIALS AND METHODS: The study groups comprised of 300 healthy parturients, divided randomly into three groups of 100 parturients each, who were administered misoprostol 400 μg through the oral (O), rectal (R), and sublingual (S) routes, respectively, during the third stage of labor. Estimation of blood loss was measured in terms of fall in hemoglobin, hematocrit, and packed cell volume (PCV) levels, and duration of the third stage of labor was also compared.
RESULTS: The mean duration for the third stage of labor was significantly shorter in group S (3.62 minutes) as compared to R (4.12 minutes), and O (4.94 minutes) (P = 0.02). The average blood loss was observed to be the least in the group S (210 ml) as compared to group R (230 ml), and group O. The incidence of shivering and fever was observed to be significantly higher (25 and 15%) in the parturients of group S (P < 0.05).
CONCLUSIONS: All routes were equally effective in managing the third stage of labor, but administration of misoprostol through the rectal route evoked better acceptability, comparable efficacy, and had an incidence of minimal side effects.
Authors:
Sukhwinder Kaur Bajwa; Sukhminder Jit Singh Bajwa; Harpreet Kaur; S P S Goraya; Anita Singh; Harpreet Kaurishar
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Perspectives in clinical research     Volume:  3     ISSN:  2229-5488     ISO Abbreviation:  Perspect Clin Res     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-11-05     Completed Date:  2012-11-06     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101551517     Medline TA:  Perspect Clin Res     Country:  India    
Other Details:
Languages:  eng     Pagination:  102-8     Citation Subset:  -    
Affiliation:
Department of Obstetrics and Gynecology, GianSagar Medical College and Hospital, Banur, Patiala, Punjab, India.
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