Document Detail

Management of suboptimal sonographic endometrial patterns in patients undergoing in-vitro fertilization and embryo transfer.
MedLine Citation:
PMID:  8473446     Owner:  NLM     Status:  MEDLINE    
A total of 816 women who underwent 1332 cycles of ovarian stimulation for in-vitro fertilization and embryo transfer (IVF/ET) had sonographic assessments of the endometrium within 2 days of oocyte retrieval. Endometrial linings were classified on the basis of thickness and echogenicity, using a grading system described previously. Grades I and IIB ('poor') were associated with a 6% viable pregnancy rate (advanced beyond 12 weeks' gestation) compared with a 29% rate for Grade IIA ('optimal'). In a subset of 112 women with poor endometrial linings during natural cycles, eight out of 21 women (38%) under 40 years of age developed optimal linings following ovarian stimulation with menotrophins, while 19 out of 91 women (21%) aged 41-45 years converted to optimal linings. Twenty-two out of 47 women (44%) who failed to develop optimal endometrial linings following ovarian stimulation converted to Grade IIA during subsequent cycles of exogenous oestrogen replacement. The financial, emotional, and physical burden associated with IVF/ET demands that patients with poor endometrial linings following ovarian stimulation with menotrophins be counselled with regard to either cancelling their cycles of treatment, or having their embryos cryopreserved for transfer to the uterus during a subsequent hormonal replacement cycle.
G Sher; S Dodge; G Maassarani; V Knutzen; C Zouves; M Feinman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  8     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-05-20     Completed Date:  1993-05-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  347-9     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Nevada School of Medicine, Northern Nevada Fertility Center, Reno 89502.
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MeSH Terms
Embryo Transfer*
Endometrium / ultrasonography*
Estradiol / analogs & derivatives,  therapeutic use
Fertilization in Vitro*
Menotropins / pharmacology
Ovary / drug effects,  physiology
Progesterone / therapeutic use
Reg. No./Substance:
50-28-2/Estradiol; 57-83-0/Progesterone; 61489-71-2/Menotropins; 979-32-8/estradiol valerate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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