Document Detail

Management of small pulmonary nodules in patients with sarcoma.
MedLine Citation:
PMID:  19466567     Owner:  NLM     Status:  MEDLINE    
Small pulmonary nodules in patients with sarcoma are problematic, because it is difficult to distinguish such small metastatic nodules from benign. The purpose of this study was to establish management guidelines for such small pulmonary nodules in patients with sarcoma. Pulmonary nodules were detected in 70 of 206 patients with sarcoma. About 55 patients were classified as having pulmonary metastasis. Seventeen of these 55 patients with pulmonary metastases were excluded from the imaging review because they did not undergo the required imaging examination. This study reviewed 38 patients with metastatic nodules and 15 patients with benign nodules. A statistically significant relationship was observed between the size of the nodules and final clinical decision. The patients with pulmonary nodules which did not exceed 5 mm in size showed significantly better cumulative overall survival rate after the detection of pulmonary nodules than those with larger nodules (5-years: 58.4 vs. 20.4%). There was no significant difference in the overall survival rate between the patients with smaller pulmonary benign lesions which did not exceed 5 mm in size and those with a normal chest CT (5-years: 92.3 vs. 85.3%). The only factor to diagnose in a metastatic pulmonary lesion is the size of the nodules. If the nodule remains < or = 5 mm in size for more than 6 months, the nodule will be a benign lesion. On the contrary, if the nodule becomes larger than 5 mm within 6 months, a surgical excision of the nodules is recommended.
Tomoki Nakamura; Akihiko Matsumine; Rui Niimi; Takao Matsubara; Katsuyuki Kusuzaki; Masayuki Maeda; Tomoyasu Tagami; Atsumasa Uchida
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Publication Detail:
Type:  Journal Article     Date:  2009-05-23
Journal Detail:
Title:  Clinical & experimental metastasis     Volume:  26     ISSN:  1573-7276     ISO Abbreviation:  Clin. Exp. Metastasis     Publication Date:  2009  
Date Detail:
Created Date:  2009-11-12     Completed Date:  2009-11-27     Revised Date:  2010-07-08    
Medline Journal Info:
Nlm Unique ID:  8409970     Medline TA:  Clin Exp Metastasis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  713-8     Citation Subset:  IM    
Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, 2-174, Edobashi, Tsu-city, Mie, 514-8507, Japan.
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MeSH Terms
Lung Neoplasms / pathology,  secondary*,  therapy
Middle Aged
Sarcoma / pathology,  secondary*,  therapy
Survival Rate

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