| Management of severe pulmonary arterial hypertension. | |
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MedLine Citation:
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PMID: 21119186 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pulmonary arterial hypertension (PAH) is a severe, progressive condition of the small pulmonary vessels that leads to increased pulmonary vascular resistance, right ventricular failure and death. Patients in World Health Organization functional class (WHO FC) IV are the most severely affected in terms of disease severity, symptomatic impairment, exercise capacity and haemodynamics, with a very poor prognosis and low survival rate. Recent developments in PAH-specific therapies have conferred significant prognostic improvements upon PAH patients, especially when coupled with management strategies such as goal-oriented therapy and combination treatment. Despite these important developments, the outlook for WHO FC IV PAH patients remains poor. This article examines the recommendations for WHO FC IV patients that appear in current PAH treatment guidelines and the research underpinning this guidance, and discusses possible future directions for treatment of this severely unwell patient population. |
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Authors:
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J-L Vachiéry; G Simonneau |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: European respiratory review : an official journal of the European Respiratory Society Volume: 19 ISSN: 1600-0617 ISO Abbreviation: Eur Respir Rev Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-01 Completed Date: 2011-03-17 Revised Date: 2012-01-10 |
Medline Journal Info:
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Nlm Unique ID: 9111391 Medline TA: Eur Respir Rev Country: Denmark |
Other Details:
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Languages: eng Pagination: 279-87 Citation Subset: IM |
Affiliation:
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Dept of Cardiology, CUB-Hôpital Erasme, Brussels, Belgium. jean-luc.vachiery@ulb.ac.be |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Drug Therapy, Combination Humans Hypertension, Pulmonary / classification, diagnosis*, therapy* Lung Transplantation Practice Guidelines as Topic Prognosis Severity of Illness Index* World Health Organization |
| Comments/Corrections | |
Comment In:
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Eur Respir Rev. 2010 Dec;19(118):264-5
[PMID:
21119183
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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