Document Detail

Management of severe COPD.
MedLine Citation:
PMID:  15351196     Owner:  NLM     Status:  MEDLINE    
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide, and the burden of the disorder will continue to increase over the next 20 years despite medical intervention. Apart from smoking cessation, no approach or agent affects the rate of decline in lung function and progression of the disease. Especially in the later phase, COPD is a multicomponent disorder, and various integrated intervention strategies are needed as part of the optimum management programme. This seminar describes largely non-pharmacological interventions aimed at improving health status and function of disabled patients. Exacerbations become progressively more troublesome as baseline lung function declines, commonly necessitating hospital admission and associated with the development of acute respiratory failure.
E F M Wouters
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Lancet     Volume:  364     ISSN:  1474-547X     ISO Abbreviation:  Lancet     Publication Date:    2004 Sep 4-10
Date Detail:
Created Date:  2004-09-07     Completed Date:  2004-09-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  England    
Other Details:
Languages:  eng     Pagination:  883-95     Citation Subset:  AIM; IM    
Department of Respiratory Medicine, University Hospital Maastricht, 6229 HX Maastricht, Netherlands.
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MeSH Terms
Acute Disease
Adrenergic beta-Agonists / therapeutic use
Edema / etiology,  physiopathology
Lung Transplantation
Pulmonary Disease, Chronic Obstructive / complications,  physiopathology,  therapy*
Respiration, Artificial / methods
Respiratory Insufficiency / etiology,  therapy
Water-Electrolyte Imbalance / etiology,  physiopathology
Weight Loss
Reg. No./Substance:
0/Adrenergic beta-Agonists

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