Document Detail


Management of sepsis in the critically ill patient: key aspects.
MedLine Citation:
PMID:  17020431     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Severe sepsis is a major cause of morbidity and mortality in the critically ill patient. Management involves identification and treatment of the underlying causative infection, with antimicrobial agents and surgery where necessary, haemodynamic resuscitation with fluids and vasoactive agents, steroids (for septic shock) and immunomodulation with drotrecogin-alpha (activated), where not contraindicated. Every effort must be made to identify sepsis early so as to optimise the patient's chances of a good outcome.
Authors:
Jean-Louis Vincent
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert opinion on pharmacotherapy     Volume:  7     ISSN:  1744-7666     ISO Abbreviation:  Expert Opin Pharmacother     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-05     Completed Date:  2006-10-11     Revised Date:  2008-04-14    
Medline Journal Info:
Nlm Unique ID:  100897346     Medline TA:  Expert Opin Pharmacother     Country:  England    
Other Details:
Languages:  eng     Pagination:  2037-45     Citation Subset:  IM    
Affiliation:
Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, B-1070 Brussels, Belgium. jlvincen@ulb.ac.be
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Infective Agents / economics,  therapeutic use*
Humans
Infection Control / methods*
Intensive Care Units / statistics & numerical data*
Multicenter Studies as Topic
Nutritional Support
Protein C / economics,  therapeutic use*
Randomized Controlled Trials as Topic
Recombinant Proteins / economics,  therapeutic use
Resuscitation / methods*
Sepsis* / drug therapy,  etiology,  mortality
Survival Analysis
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 0/Protein C; 0/Recombinant Proteins; 0/drotrecogin alfa activated

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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