Document Detail

Management of sepsis: early resuscitation.
MedLine Citation:
PMID:  18954703     Owner:  NLM     Status:  MEDLINE    
Key links in the chain of survival for the management of severe sepsis and septic shock are early identification and comprehensive resuscitation of high-risk patients. Multiple studies have shown that the first 6 hours of early sepsis management are especially important from a diagnostic, pathogenic, and therapeutic perspective, and that steps taken during this period can have a significant impact on outcome. The recognition of this critical time period and the robust outcome benefit realized in previous studies provides the rationale for adopting early resuscitation as a distinct intervention. Sepsis joins trauma, stroke, and acute myocardial infarction in having "golden hours," representing a critical opportunity early on in the course of disease for actions that offer the most benefit.
Emanuel P Rivers; Victor Coba; Alvaro Visbal; Melissa Whitmill; David Amponsah
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinics in chest medicine     Volume:  29     ISSN:  1557-8216     ISO Abbreviation:  Clin. Chest Med.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-10-28     Completed Date:  2009-03-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7907612     Medline TA:  Clin Chest Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  689-704, ix-x     Citation Subset:  IM    
Department of Emergency Medicine, Henry Ford Health Systems, 270-Clara Ford Pavilion, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
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MeSH Terms
Calcitonin / blood
Critical Care
Hemodynamics / physiology
Lactic Acid / blood
Multiple Organ Failure / mortality,  physiopathology,  prevention & control
Natriuretic Peptide, Brain / blood
Protein Precursors / blood
Resuscitation / methods*
Sepsis / mortality,  physiopathology,  therapy*
Shock, Septic / mortality,  physiopathology,  therapy*
Survival Rate
Troponin / blood
Reg. No./Substance:
0/Protein Precursors; 0/Troponin; 114471-18-0/Natriuretic Peptide, Brain; 50-21-5/Lactic Acid; 56645-65-9/procalcitonin; 9007-12-9/Calcitonin

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