| Management of sepsis: early resuscitation. | |
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MedLine Citation:
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PMID: 18954703 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Key links in the chain of survival for the management of severe sepsis and septic shock are early identification and comprehensive resuscitation of high-risk patients. Multiple studies have shown that the first 6 hours of early sepsis management are especially important from a diagnostic, pathogenic, and therapeutic perspective, and that steps taken during this period can have a significant impact on outcome. The recognition of this critical time period and the robust outcome benefit realized in previous studies provides the rationale for adopting early resuscitation as a distinct intervention. Sepsis joins trauma, stroke, and acute myocardial infarction in having "golden hours," representing a critical opportunity early on in the course of disease for actions that offer the most benefit. |
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Authors:
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Emanuel P Rivers; Victor Coba; Alvaro Visbal; Melissa Whitmill; David Amponsah |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Clinics in chest medicine Volume: 29 ISSN: 1557-8216 ISO Abbreviation: Clin. Chest Med. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-10-28 Completed Date: 2009-03-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7907612 Medline TA: Clin Chest Med Country: United States |
Other Details:
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Languages: eng Pagination: 689-704, ix-x Citation Subset: IM |
Affiliation:
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Department of Emergency Medicine, Henry Ford Health Systems, 270-Clara Ford Pavilion, 2799 West Grand Boulevard, Detroit, MI 48202, USA. erivers1@hfhs.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Calcitonin
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blood Critical Care Hemodynamics / physiology Humans Lactic Acid / blood Multiple Organ Failure / mortality, physiopathology, prevention & control Natriuretic Peptide, Brain / blood Prognosis Protein Precursors / blood Resuscitation / methods* Sepsis / mortality, physiopathology, therapy* Shock, Septic / mortality, physiopathology, therapy* Survival Rate Troponin / blood |
| Chemical | |
Reg. No./Substance:
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0/Protein Precursors; 0/Troponin; 114471-18-0/Natriuretic Peptide, Brain; 50-21-5/Lactic Acid; 56645-65-9/procalcitonin; 9007-12-9/Calcitonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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