Document Detail


Management of rhesus isoimmunization by preimplantation genetic diagnosis.
MedLine Citation:
PMID:  9238659     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A genetic assay by single blastomere analysis was developed for rhesus (RhD) blood group typing of early cleavage stage embryos. The method, which is based on the simultaneous amplification of an RhD-specific sequence and an internal control in single cells, was applied for the selective transfer of RhD-negative embryos in a family of an RhD sensitized woman and a heterozygote partner. The RhD status of two out of three biopsied embryos was determined. According to their amplified products, both were typed as RhD-negative and transferred to the uterus. Pregnancy was not achieved.
Authors:
R Avner; B E Reubinoff; A Simon; B S Zentner; A Friedmann; S Mitrani-Rosenbaum; N Laufer
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular human reproduction     Volume:  2     ISSN:  1360-9947     ISO Abbreviation:  Mol. Hum. Reprod.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1997-09-11     Completed Date:  1997-09-11     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9513710     Medline TA:  Mol Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  60-2     Citation Subset:  IM    
Affiliation:
Unit for Molecular Biology and Genetic Engineering, Hadassah University Hospital, Mount-Scopus, Jerusalem, Israel.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biopsy
Blastocyst / immunology*
Blastomeres / immunology*,  pathology
Blood Grouping and Crossmatching / methods
DNA / analysis
DNA Primers / diagnostic use
Embryo Transfer
Female
Fertilization in Vitro*
Genetic Testing
Genotype
Humans
Male
Polymerase Chain Reaction
Rh Isoimmunization / diagnosis,  genetics*
Rho(D) Immune Globulin / genetics
Spermatozoa / immunology*
Chemical
Reg. No./Substance:
0/DNA Primers; 0/Rho(D) Immune Globulin; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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