Document Detail


Management of pterygia: should thiotepa be used?
MedLine Citation:
PMID:  98089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pterygium, a common source of morbidity throughout the world, may appear to be an innocuous, easily excised lesion, yet it plagues the ophthalmologist by its high rate of recurrence, ranging from 20% to 30% after simple excision. Beta irradiation has been used by ophthalmic surgeons for many years. Another method of stemming the high percentage of pterygium recurrence is through local application of thiotepa, a radiomimetic drug that inhibits rapidly proliferating cells. The following report is a review of the literature from 1960 to 1977 on the role of thiotepa in treatment of pterygium, with emphasis on the complications of thiotepa administration. The recurrence rate after topical postoperative use of thiotepa ranges from 0 to 8%, with disturbing variance in results, depending on each investigator's definition of "recurrence", the length of follow-up, the type of pterygium, and the number of patients. The main reported complication from thiotepa's use has been depigmentation of skin around several patients' eyes, sometimes precipitated by exposure to the sun's rays.
Authors:
K Olander; K G Haik; G M Haik
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of ophthalmology     Volume:  10     ISSN:  0003-4886     ISO Abbreviation:  Ann Ophthalmol     Publication Date:  1978 Jul 
Date Detail:
Created Date:  1978-09-30     Completed Date:  1978-09-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0210137     Medline TA:  Ann Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  853-62     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Pigmentation Disorders / chemically induced
Pterygium / classification,  drug therapy*,  surgery
Recurrence
Sunlight
Thiotepa / adverse effects,  therapeutic use*
Chemical
Reg. No./Substance:
52-24-4/Thiotepa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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