Document Detail

Management of psychosis associated with a prolactinoma: case report and review of the literature.
MedLine Citation:
PMID:  20833935     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Prolactinomas are the most common pituitary tumors; they are treated with dopamine agonists, which may cause psychotic symptoms as a side effect. Psychosis is treated with dopamine-receptor blockers that may result in elevated serum prolactin and symptomatic hyperprolactinemia.
OBJECTIVE: The authors will review a case of a patient with a prolactinoma as well as schizophrenia and illustrate the management of psychosis in this case.
METHOD: The review describes the management of prolactinoma, symptoms of hyperprolactinemia, and long-term effects of hyperprolactinemia.
RESULTS: In the case presentation reviewed, the patient was finally discharged on risperidone long-acting injection and testosterone supplementation, with no growth of the adenoma after 3 years.
DISCUSSION: This review provides recommendations and treatment strategy for management of prolactinoma in a patient with schizophrenia.
Shirin Ali; Karen Klahr Miller; Oliver Freudenreich
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Psychosomatics     Volume:  51     ISSN:  1545-7206     ISO Abbreviation:  Psychosomatics     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-09-13     Completed Date:  2011-01-11     Revised Date:  2013-06-04    
Medline Journal Info:
Nlm Unique ID:  0376506     Medline TA:  Psychosomatics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  370-6     Citation Subset:  IM    
McLean Hospital, Boston, MA, USA.
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MeSH Terms
Dopamine Agonists / adverse effects,  therapeutic use
Dopamine Antagonists / adverse effects,  therapeutic use
Magnetic Resonance Imaging
Pituitary Neoplasms / complications*,  diagnosis,  drug therapy,  surgery
Prolactin / blood
Prolactinoma / complications*,  diagnosis,  drug therapy,  surgery
Risperidone / adverse effects,  therapeutic use
Schizophrenia / complications*,  drug therapy
Grant Support
Reg. No./Substance:
0/Dopamine Agonists; 0/Dopamine Antagonists; 106266-06-2/Risperidone; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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