Document Detail


Management protocol for abacavir-related hypersensitivity reaction.
MedLine Citation:
PMID:  10676833     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To develop an abacavir hypersensitivity reaction management protocol for the University of Oklahoma Health Sciences Center. DATA SYNTHESIS: Conference abstracts, published literature, and manufacturer-provided materials were reviewed to define the syndrome and manifestations and to recommend steps to take when a patient develops abacavir-related reactions. RESULTS: Initial education, formalized contact and response mechanism, and intervention levels were incorporated into a protocol for clinicians. CONCLUSIONS: Abacavir, a newly approved agent for the treatment of HIV, has been associated with a fatal hypersensitivity reaction. Our protocol provides a mechanism to minimize progression of abacavir hypersensitivity reaction by providing a formalized management procedure.
Authors:
P G Clay; R C Rathbun; L N Slater
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Annals of pharmacotherapy     Volume:  34     ISSN:  1060-0280     ISO Abbreviation:  Ann Pharmacother     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-03-08     Completed Date:  2000-03-08     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9203131     Medline TA:  Ann Pharmacother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  247-9     Citation Subset:  IM; X    
Affiliation:
Fellow of Infectious Diseases, College of Pharmacy, University of Oklahoma, Oklahoma City, USA. pclay@cctr.umkc.edu
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MeSH Terms
Descriptor/Qualifier:
Anti-HIV Agents / adverse effects*,  contraindications,  therapeutic use
Dideoxynucleosides / adverse effects*,  contraindications,  therapeutic use
Drug Hypersensitivity / therapy*
HIV Infections / complications,  drug therapy
Humans
Chemical
Reg. No./Substance:
0/Anti-HIV Agents; 0/Dideoxynucleosides; 0/abacavir

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