Document Detail

Management of proteinuria secondary to penicillamine therapy in rheumatoid arthritis.
MedLine Citation:
PMID:  1617896     Owner:  NLM     Status:  MEDLINE    
To determine if a policy of continuing penicillamine therapy in successfully treated patients with rheumatoid arthritis in the presence of persistent proteinuria, was associated or not with resolution of this adverse effect, a computer record of patients receiving penicillamine for rheumatoid arthritis was searched for patients with persistent proteinuria and the case notes of these patients reviewed. Eleven patients with persistent proteinuria were identified, eight of whom did not have nephrotic syndrome and were continued on penicillamine with close monitoring. In 5 patients proteinuria resolved after 16-21 months; 3 developed peripheral oedema (2) or worsening of pre-existing hypertension and proteinuria (1). In one of these the proteinuria subsequently resolved and one died of unknown cause. Of the 3 initially nephrotic patients, two had resolved at the time of the study. Persistent proteinuria in penicillamine-treated patients with rheumatoid arthritis resolves with continued therapy in the absence of nephrotic syndrome but vigilance is required for the development of any complications.
R N DeSilva; C J Eastmond
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical rheumatology     Volume:  11     ISSN:  0770-3198     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-08-04     Completed Date:  1992-08-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  216-9     Citation Subset:  IM    
Department of Rheumatology, City Hospital, Aberdeen, Scotland.
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MeSH Terms
Arthritis, Rheumatoid / drug therapy*
Penicillamine / adverse effects,  therapeutic use*
Proteinuria / chemically induced*,  urine
Reg. No./Substance:

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