Document Detail

Management of prenatally detected nonlethal fetal anomalies: is a karyotype of benefit?
MedLine Citation:
PMID:  1741869     Owner:  NLM     Status:  MEDLINE    
The pregnancy outcomes of 155 women who underwent an amniocentesis for a prenatal karyotype after being diagnosed by ultrasound as having one or more nonlethal structural anomalies are presented. Thirty-three (21%) patients were found to have an abnormal karyotype. Knowledge of the prenatal karyotype was useful in the subsequent management of these pregnancies. A pregnancy with a fetal anomaly diagnosed prior to 24 weeks was more likely to be terminated if an abnormal karyotype was also present. In women who were diagnosed as having a fetal anomaly with an abnormal karyotype at 24 weeks or later, only 3 of 13 (23%) infants survived the neonatal period. Knowledge of the karyotype results influenced decisions regarding the place, timing, and route of delivery in these fetuses. In 32 women, (21%) a karyotype was beneficial by avoiding maternal transport, cesarean delivery, and neonatal expenses at a Level III perinatal center.
C G Brumfield; R O Davis; J C Hauth; P Cosper; E V Colvin; S C Finley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of perinatology     Volume:  8     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1992-01-16     Completed Date:  1992-01-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  255-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Alabama, Birmingham.
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MeSH Terms
Abortion, Induced
Chromosome Aberrations / diagnosis*
Chromosome Disorders
Congenital Abnormalities / genetics*,  therapy,  ultrasonography
Fetal Death / etiology
Infant Mortality
Infant, Newborn
Pregnancy Outcome
Ultrasonography, Prenatal

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