| Management of prenatally detected nonlethal fetal anomalies: is a karyotype of benefit? | |
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MedLine Citation:
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PMID: 1741869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pregnancy outcomes of 155 women who underwent an amniocentesis for a prenatal karyotype after being diagnosed by ultrasound as having one or more nonlethal structural anomalies are presented. Thirty-three (21%) patients were found to have an abnormal karyotype. Knowledge of the prenatal karyotype was useful in the subsequent management of these pregnancies. A pregnancy with a fetal anomaly diagnosed prior to 24 weeks was more likely to be terminated if an abnormal karyotype was also present. In women who were diagnosed as having a fetal anomaly with an abnormal karyotype at 24 weeks or later, only 3 of 13 (23%) infants survived the neonatal period. Knowledge of the karyotype results influenced decisions regarding the place, timing, and route of delivery in these fetuses. In 32 women, (21%) a karyotype was beneficial by avoiding maternal transport, cesarean delivery, and neonatal expenses at a Level III perinatal center. |
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Authors:
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C G Brumfield; R O Davis; J C Hauth; P Cosper; E V Colvin; S C Finley |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of perinatology Volume: 8 ISSN: 0735-1631 ISO Abbreviation: Am J Perinatol Publication Date: 1991 Jul |
Date Detail:
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Created Date: 1992-01-16 Completed Date: 1992-01-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8405212 Medline TA: Am J Perinatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 255-8 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Alabama, Birmingham. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Induced Adult Amniocentesis Chromosome Aberrations / diagnosis* Chromosome Disorders Congenital Abnormalities / genetics*, therapy, ultrasonography Female Fetal Death / etiology Humans Infant Mortality Infant, Newborn Karyotyping* Pregnancy Pregnancy Outcome Ultrasonography, Prenatal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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