Document Detail

Management of peripheral arterial disease of the lower extremities.
MedLine Citation:
PMID:  18025617     Owner:  NLM     Status:  MEDLINE    
Smoking should be stopped and hypertension, diabetes mellitus, dyslipidemia, and hypothyroidism treated in patients with peripheral arterial disease (PAD) of the lower extremities. Statins decrease the incidence of intermittent claudication and improve exercise duration until the onset of intermittent claudication in persons with PAD and hypercholesterolemia. Antiplatelet drugs such as aspirin or clopidogrel, especially clopidogrel, angiotensin-converting enzyme inhibitors, and statins should be given to all persons with PAD. Beta blockers should be given if coronary artery disease is present. Exercise rehabilitation programs and cilostazol increase exercise time until intermittent claudication develops. Chelation therapy should be avoided. Indications for lower extremity percutaneous transluminal angioplasty or bypass surgery are (1) incapacitating claudication in persons interfering with work or lifestyle, (2) limb salvage in persons with limb-threatening ischemia as manifested by rest pain, nonhealing ulcers, and/or infection or gangrene, and (3) vasculogenic impotence.
Wilbert S Aronow
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Comprehensive therapy     Volume:  33     ISSN:  0098-8243     ISO Abbreviation:  Compr Ther     Publication Date:  2007  
Date Detail:
Created Date:  2007-11-20     Completed Date:  2008-03-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605837     Medline TA:  Compr Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  247-56     Citation Subset:  IM    
Department of Medicine, Division of Cardiology, New York Medical College, Valhalla, NY 10595, USA.
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MeSH Terms
Angioplasty, Balloon
Atherosclerosis / complications
Cardiovascular Agents / therapeutic use
Intermittent Claudication / etiology,  prevention & control
Lower Extremity / blood supply
Peripheral Vascular Diseases / etiology,  therapy*
Platelet Aggregation Inhibitors / therapeutic use
Risk Factors
Smoking Cessation
Vascular Surgical Procedures
Reg. No./Substance:
0/Cardiovascular Agents; 0/Platelet Aggregation Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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