Document Detail

Management of pericardial diseases during pregnancy.
MedLine Citation:
PMID:  20389257     Owner:  NLM     Status:  MEDLINE    
Relatively few data have been published on the management of pericardial diseases during pregnancy. Pericardial involvement is sporadic during pregnancy, and pregnant women do not show any specific predisposition to pericardial diseases. The more common form of pericardial involvement is hydropericardium, usually as a benign mild effusion recorded in about 40% of pregnant women by the third trimester, followed by pericarditis as the more common disease requiring medical therapy. The general management of these conditions is not different from those of nonpregnant women, although specific precautions should be followed for specific diagnostic and therapeutic issues during pregnancy. If possible, pregnancy should be planned in a phase of disease quiescence. Nonselective cyclooxygenase inhibitors and aspirin can be used safely during the first and second trimester, but should be withdrawn later and in any case at gestational week 32, because of the possible effects on ductus arteriosus and renal function. Low-medium doses of prednisone are allowed during all pregnancy and breastfeeding. Colchicine is generally contraindicated during pregnancy, except in women with familial Mediterranean fever. These pregnancies should be followed by a dedicated multidisciplinary teams.
Massimo Imazio; Antonio Brucato; Stefania Rampello; Flavio Armellino; Rita Trinchero; David H Spodick; Yehuda Adler
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cardiovascular medicine (Hagerstown, Md.)     Volume:  11     ISSN:  1558-2035     ISO Abbreviation:  J Cardiovasc Med (Hagerstown)     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-06-30     Completed Date:  2010-10-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101259752     Medline TA:  J Cardiovasc Med (Hagerstown)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  557-62     Citation Subset:  IM    
Cardiology Department, Maria Vittoria Hospital, Torino, Italy.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use
Anti-Inflammatory Agents / adverse effects,  contraindications,  therapeutic use*
Aspirin / therapeutic use
Colchicine / contraindications
Cyclooxygenase Inhibitors / therapeutic use
Pericardial Effusion / diagnosis,  drug therapy*
Pericarditis / diagnosis,  drug therapy*
Prednisone / therapeutic use
Pregnancy Complications, Cardiovascular / diagnosis,  drug therapy*
Treatment Outcome
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Anti-Inflammatory Agents; 0/Cyclooxygenase Inhibitors; 50-78-2/Aspirin; 53-03-2/Prednisone; 64-86-8/Colchicine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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