Document Detail


Management of patients diagnosed with lobular carcinoma in situ at needle core biopsy at a community-based outpatient facility.
MedLine Citation:
PMID:  22268169     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: The objective of our study was to show the importance of surgical excision after the diagnosis of lobular carcinoma in situ (LCIS) based on needle core biopsy.
MATERIALS AND METHODS: Retrospective evaluation of all cases of LCIS diagnosed at needle core biopsy from 2000 to 2011 was performed; 60 patients with 64 diagnoses of LCIS comprise the cohort. Data recorded included patient demographics, patient presentation, breast density, personal and family histories of breast cancer, lesion characteristics, biopsy method, and correlation of core results with surgical pathology or follow-up imaging. The pathology facility was recorded for all biopsies because the specimens from open surgical biopsy were frequently reviewed by a different laboratory.
RESULTS: A total of 60 patients with 64 diagnoses of LCIS comprised the study cohort. The patients ranged in age from 36 to 93 years (average, 55 years). The lesions consisted of 39 calcifications, two masses with calcium, 10 masses, two asymmetries, two architectural distortions, two architectural distortions with calcifications, and seven MRI enhancements. Mammography detected lesions in 84% of the cases (n = 54) and 16% (n = 10) were not visualized. Sonography detected lesions in 30% of the cases (n = 19) and 70% (n = 45) were sonographically occult. Needle core biopsy was performed in all cases: 49 stereotactic biopsies (77%), 12 ultrasound-guided biopsies, and three MRI-guided biopsies. All but one case proceeded to surgery. Open surgical biopsy revealed 21 cancers (33%); of the remaining cases, 53% of the cases (n = 33) were atypical or high risk and 14% (n = 9) were benign.
CONCLUSION: The diagnosis of LCIS at needle core biopsy, in this small study, revealed that 84% of lesions either were malignant or were atypical or high risk at surgery, of which 33% were found to be carcinoma. Our findings suggest that LCIS should be excised when noted at core biopsy.
Authors:
Stamatia V Destounis; Philip F Murphy; Posy J Seifert; Patricia A Somerville; Andrea L Arieno; Renee C Morgan; Wende Logan Young
Related Documents :
22104579 - Two cases of temporal bone metastases as presenting sign of lung cancer.
24209399 - An ischaemic thalamic lesion extending to the mammillothalamic tract associated with ab...
1593019 - Churg-strauss syndrome: report of a case without preexisting asthma.
22131649 - Lymphoepithelial cyst of the pancreas: a rare case report and review of literature.
3545019 - Synergistic effects of sequential carbon dioxide and neodymium:yttrium aluminum garnet ...
21741159 - Current pathology keys of renal cell carcinoma.
19682759 - Core needle biopsies for determination of the microenvironment in individual tumours fo...
9831839 - Primary low-grade, b-cell, mucosa-associated lymphoid tissue lymphoma of the colorectum...
15130079 - Glandular odontogenic cyst: case report and review of the literature.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  198     ISSN:  1546-3141     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  281-7     Citation Subset:  AIM; IM    
Affiliation:
Elizabeth Wende Breast Care, LLC, 170 Saw-grass Dr, Rochester, NY 14620.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Nonsurgical management of high-risk lesions diagnosed at core needle biopsy: can malignancy be ruled...
Next Document:  Surgical outcome of biopsy-proven lobular neoplasia: is there any difference between lobular carcino...