Document Detail


Management of a patient with a mechanical aortic valve and antibodies to both thrombin and factor V after repeat exposure to fibrin sealant.
MedLine Citation:
PMID:  10815789     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We describe a patient who developed a markedly prolonged PT, PTT, and thrombin time 13 days after repeat exposure to fibrin sealant during coronary artery bypass grafting and aortic valve replacement. Evaluation revealed an inhibitor to bovine thrombin that cross-reacted with human thrombin. In addition an inhibitor to human coagulation factor V was identified. Despite coagulation abnormalities there was no evidence of bleeding. Nevertheless, effective anticoagulation was required to minimize the thrombotic complications associated with the patient's prosthetic valve. We elected to take a conservative approach and not utilize pharmacologic anticoagulation until there was diminution in the effect of the acquired inhibitors. We report on our patient's course and review the available literature addressing the management of patients demonstrating inhibitors to blood coagulation factors after repeat exposure to fibrin sealants.
Authors:
M S Zumberg; J M Waples; K J Kao; R Lottenberg
Related Documents :
1934449 - Growth and cell viability of aortic versus pulmonic homografts in the systemic circulat...
21769839 - Improving the detection of pulmonary hypertension in systemic sclerosis using pulmonary...
22083429 - Pulmonary arterial hypertension: an update.
10196619 - Ureter and bladder replacement following radical cystectomy.
15734409 - Tracheal regeneration following tracheal replacement with an allogenic aorta.
17059929 - Superior outcomes for repair in infants and neonates with tetralogy of fallot with abse...
8590999 - Specificity of different organic nitrates to elicit no formation in rabbit vascular tis...
9689799 - Long-term treatment with cyclosporin a and coumarin in pulmonary thromboembolic behçet'...
15275629 - Distal endothelial function and vascular morphology after catheter-based radiation in p...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of hematology     Volume:  64     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-05-31     Completed Date:  2000-05-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  59-63     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Florida, Gainesville 32610, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Animals
Antibody Specificity
Autoimmunity*
Cattle
Cross Reactions
Factor V / immunology*
Fibrin Tissue Adhesive / adverse effects*,  immunology
Heart Valve Prosthesis*
Heart Valve Prosthesis Implantation / adverse effects*
Humans
Male
Thrombin / immunology*
Chemical
Reg. No./Substance:
0/Fibrin Tissue Adhesive; 9001-24-5/Factor V; EC 3.4.21.5/Thrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Familial myelodysplastic syndrome with early age of onset.
Next Document:  HTLV-1 unrelated adult T-cell leukemia/lymphoma with unique phenotype and karyotype.