| Management of pain in cancer patients with depression and cognitive deterioration. | |
| | |
MedLine Citation:
|
PMID: 19969448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Patients with cancer are burdened with pain, ranging in prevalence from 14 to 100% in this population, and with comorbid behavioural symptoms such as depression and cognitive decline. However, the complex relationships between cancer pain, depression and cognitive decline, as well as their causes, still need to be clarified. Here, the existing literature on pain and its relationships with depression and cognitive decline in adult patients with cancer is reviewed, in order to understand the impact of pain on these interrelated symptoms, and the importance of its correct assessment and management. From the literature, it emerges that pain in cancer patients has a multidimensional phenomenology, which is the final product of a complex process involving emotional, cognitive, and sensory components. There is a substantial agreement that cancer patients with pain are at higher risk of having depression and cognitive decline. However, it is still controversial if these symptoms may fit into the same cluster, due to the paucity of studies exploring the simultaneous impact of pain on the psychological and cognitive well-being of patients with cancer, which would be consequential on their treatment and management. Finally, recent advances in immunology/oncology have provided novel insights into the pathophysiologic mechanisms supposedly underlying pain-related symptoms. Particularly, immune dysfunction may represent a common pathogenic ground of pain, depression and cognitive decline in cancer patients. In clinical practice, an appropriate assessment of pain should take into account the relationships with depression and cognitive decline, in order to develop more personalised and effective therapies for its management. |
| | |
Authors:
|
Ilaria Spoletini; Carlo Caltagirone; Moira Ceci; Walter Gianni; Gianfranco Spalletta |
Related Documents
:
|
18555148 - The role of neurolytic celiac plexus block in the treatment of pancreatic cancer pain. 18065118 - Music and cancer pain management. 12955928 - Neuropathic pain in patients with cancer. 15589088 - Characterization of the early pharmacodynamic profile of oral methadone for cancer-rela... 15881728 - Treatment planning dilemmas resulting from failed root canal cases. 2897378 - Operative andrology. |
Publication Detail:
|
Type: Journal Article; Review Date: 2009-12-06 |
Journal Detail:
|
Title: Surgical oncology Volume: 19 ISSN: 1879-3320 ISO Abbreviation: Surg Oncol Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-08-20 Completed Date: 2010-12-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9208188 Medline TA: Surg Oncol Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 160-6 Citation Subset: IM |
Copyright Information:
|
Copyright 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
|
IRCCS Santa Lucia Foundation, Rome, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Cognition Disorders / therapy* Depressive Disorder / therapy* Humans Neoplasms / therapy* Pain / therapy* Psychotherapy |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: [F(18)]-fluoroethylcholine combined in-line PET-CT scan for detection of lymph-node metastasis in hi...
Next Document: Enzymatic synthesis of eugenol benzoate by immobilized Staphylococcus aureus lipase: Optimization us...