Document Detail

Management and outcome of metastatic melanoma during pregnancy.
MedLine Citation:
PMID:  19804595     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although metastatic melanoma occurrence during pregnancy challenges the physician in several ways, only a few studies have been published. OBJECTIVES: Our aim was to investigate therapeutic management together with maternal and fetal outcomes in pregnant women with advanced melanoma. METHODS: A French national retrospective study was conducted in 34 departments of Dermatology or Oncology. All patients with American Joint Committee on Cancer (AJCC) stage III/IV melanoma diagnosed during pregnancy were included. Data regarding melanoma history, pregnancy, treatment, delivery, maternal and infant outcomes were collected. RESULTS: Twenty-two women were included: 10 AJCC stage III and 12 stage IV. Abortion was performed in three patients. Therapeutic abstention during pregnancy was observed in three cases, 14 patients underwent surgery, four patients received chemotherapy and one patient was treated with brain radiotherapy alone. The median gestational age was 36 weeks amenorrhoea. Neither neonatal metastases nor deformities were observed. Placenta metastases were found in one case. Among 18 newborns, 17 are currently alive (median follow up, 17 months); one died of sudden infant death. The 2-year maternal survival rates were 56% (stage III) and 17% (stage IV). CONCLUSIONS: Faced with metastatic melanoma, a majority of women chose to continue with pregnancy, giving birth, based on our samples, to healthy, frequently premature infants. Except during the first trimester of pregnancy, conventional melanoma treatment was applied. No serious side effect was reported, except one case of miscarriage after surgery. Mortality rates do not suggest a worsened prognosis due to pregnancy but larger prospective controlled studies are necessary to assess this specific point.
C Pag?s; C Robert; L Thomas; E Maubec; B Sassolas; F Granel-Brocard; C Chevreau; S De Raucourt; M-T Leccia; D Fichet; A Khammari; F Boitier; P-E Stoebner; S Dalac; P Celerier; F Aubin; M Viguier
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Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2009-05-21
Journal Detail:
Title:  The British journal of dermatology     Volume:  162     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-04-08     Completed Date:  2010-05-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  274-81     Citation Subset:  IM    
Service de Dermatologie, Universit? Paris VII, H?pital Saint-Louis, INSERM U697, 1 Avenue Claude-Vellefaux, 75475 Paris Cedex 10, France.
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MeSH Terms
Melanoma / mortality,  pathology,  secondary,  therapy*
Placenta / pathology
Pregnancy Complications, Neoplastic / mortality,  pathology,  therapy*
Pregnancy Outcome
Retrospective Studies
Risk Assessment
Skin Neoplasms / mortality,  pathology,  therapy*
Survival Rate
Treatment Outcome
Young Adult

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