Document Detail

Management options and prognosis of pancreatic adenocarcinoma at 16 weeks' gestation: a case report.
MedLine Citation:
PMID:  22523879     Owner:  NLM     Status:  In-Process    
BACKGROUND: Antepartum diagnosis of pancreatic adenocarcinoma is extremely rare, with only 9 cases previously reported in the literature. We report on such a case and review the literature for management options and prognosis of this unfortunate condition.
CASE: A 33-year-old woman, gravida 1, para 0, was referred at 16 weeks' gestation due to weakness, weight loss and anemia. Comprehensive investigation followed and a final diagnosis of pancreatic adenocarcinoma was made after pancreatic fine needle aspiration biopsy during endoscopic ultrasound of the upper abdomen. At 19 weeks' gestation fetal demise occurred.
CONCLUSION: While early diagnosis may not alter long-term outcome, it may provide the patient with an earlier opportunity to evaluate decisions related to pregnancy. The two most important factors determining management options for pancreatic cancer during pregnancy are disease stage and gestational age. Prognosis is extremely poor, with 5-year survival after surgery being 20% versus 3-5% in unresectable disease. Prognosis depends on disease stage and on the interval between diagnosis and surgery. Delay for even one month may render the disease metastatic. Participation of a multidisciplinary team is critical in the management of such cases since, due to the rarity of the disease during pregnancy, there are no evidence-based data to guide decisionmaking.
Dimitrios Papoutsis; Michael Sindos; Nikolaos Papantoniou; Aris Antsaklis
Related Documents :
17567299 - Evaluation of the effectiveness of a broad-spectrum sunscreen in the prevention of chlo...
21729009 - High positive antibody titers and adverse pregnancy outcome in women with antiphospholi...
18992679 - Soluble and membranous vascular endothelial growth factor receptor-1 in pregnancies com...
22790629 - A case of severe acute pancreatitis with hyperlipidemia in a pregnant woman.
15327129 - Electrocorticogram spectral analysis and somatosensory evoked potentials as tools to as...
2765429 - Histological features of uteroplacental vessels in normal and hypertensive patients in ...
12442599 - Clinical risk factors for deep venous thrombosis in pregnancy and the puerperium.
606579 - Mortality and fertility control.
1500099 - Arachidonic acid metabolites: effects on inflammation of fetal rabbit excisional wounds.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  57     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:    2012 Mar-Apr
Date Detail:
Created Date:  2012-04-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  167-70     Citation Subset:  IM    
First Department of Obstetrics and Gynecology, University of Athens, Alexandra Hospital, Athens, Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Utilization of instruments in the chairman's curio cabinet: a case report.
Next Document:  Spontaneous pregnancy reaches viability after low first trimester serum progesterone: a case report.